1028-00-8Relevant academic research and scientific papers
Regio- And Stereoselective Addition of Bronsted Acids to Yndiamides: Synthesis of N, O, N - And N, S, N -Trisubstituted Ketene Acetals
Anderson, Edward A.,Garry, Olivia L.,Mansfield, Steven J.
, p. 4221 - 4230 (2021/10/04)
Yndiamides, N,N-disubstituted alkynes, are versatile building blocks for the synthesis of nitrogen-containing organic molecules. Unlike ynamides, relatives that are inherently polarized by a single nitrogen substituent, their pseudo-symmetric nature renders regioselective reactions challenging. Here we report investigations into the regioselective addition of Br nsted acids to non-symmetric yndiamides, a reaction that delivers N,O,N- and N,S,N-trisubstituted ketene acetals with excellent regio- and stereoselectivity.
Synthesis and antimicrobial activity of 2-aryloxy-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxides
Raghu,Devendranath Reddy
, p. 1228 - 1232 (2007/10/03)
A series of 2-aryloxy-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxides have been synthesized by condensing 2,2-dimethyl-1,3-propanediol with various arylphosphorodichloridates. Some of these compounds are prepared by reacting the monochloride, 2-chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide, in situ with some substituted phenols. The monochloride is prepared by condensing 2,2-dimethyl-1,3-propanediol with phosphorus oxychloride. Their structures have been confirmed by elemental analyses, IR, 1H, 13C and 31P NMR and mass spectral studies. All these compounds are screened for their antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis and Staphylococcus aureus and antifungal activity against Curvularia lunata, Fusarium oxysporum and Helmeinthosporium oryzae.
