1028058-67-4Relevant academic research and scientific papers
Synthesis of chalcone derivatives on steroidal framework and their anticancer activities
Saxena, Hari Om,Faridi, Uzma,Kumar,Luqman, Suaib,Darokar,Shanker, Karuna,Chanotiya, Chandan S.,Gupta,Negi, Arvind S.
, p. 892 - 900 (2008/02/13)
Chalcone derivatives on estradiol framework have been synthesized. Some of the derivatives showed potent anticancer activity against some human cancer cell lines. Compounds 9 and 19 showed potent activity against MCF-7, a hormone dependent breast cancer cell line. Chalcone 7 was further modified to the corresponding indanone derivative (19) using the Nazarov reaction, which showed better activity than the parent compound against the MCF-7 breast cancer cell line. Active anticancer derivatives were also evaluated for osmotic hemolysis using the erythrocyte as a model system. It was observed that chalcone derivatives showing cytotoxicity against cancer cell lines did not affect the fragility of erythrocytes and hence may be considered as non-toxic to normal cells.
