102806-25-7

Basic information

• Product Name: 2-(benzyloxy)-1,1′-biphenyl
• Synonyms: 2-(benzyloxy)-1,1′-biphenyl
• CAS NO: 102806-25-7
• Molecular Weight: 260.335
• Mol File: 102806-25-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(benzyloxy)-1,1′-biphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzyloxy)-1,1′-biphenyl(102806-25-7)
• EPA Substance Registry System: 2-(benzyloxy)-1,1′-biphenyl(102806-25-7)

Safety Data

• Hazardous Substances Data: 102806-25-7(Hazardous Substances Data)

Upstream product

• 63591-85-5 phenylacetic acid N-hydroxysuccinimide ester 
• 90-43-7 2-Phenylphenol 
• 103-82-2 phenylacetic acid 
• 201405-69-8 2′-(benzyloxy)-[1,1′-biphenyl]-2-ol 
• 260783-80-0 N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate 
• 98-80-6 phenylboronic acid 
• 6272-38-4 O-benzylcatechol 
• 100-44-7 benzyl chloride 

Relevant articles and documents

Homogeneous Palladium-Catalyzed Selective Reduction of 2,2′-Biphenols Using HCO 2H as Hydrogen Source

An efficient homogeneous palladium-catalyzed selective deoxygenation of 2,2′-biphenols by reduction of aryl triflates with HCO 2H as the hydrogen source is reported. This protocol complements the current method based on heterogeneous Pd/C-catalyzed hydrogenation with hydrogen gas. This process provided the reduction products in good to excellent yields, which could be readily converted to various synthetically useful molecules, especially ligands for catalytic synthesis.

Transition-Metal-Free and Base-Promoted Carbon-Heteroatom Bond Formation via C-N Cleavage of Benzyl Ammonium Salts

A facile and general method for constructing carbon-heteroatom (C-P, C-O, C-S, and C-N) bonds via C-N cleavage of benzyl ammonium salts under transition-metal-free conditions was reported. The combination of t-BuOK and 18-crown-6 enabled a wide range of substituted benzyl ammonium salts to couple readily with different kinds of heteroatom nucleophiles, i.e. hydrogen phosphoryl compounds, alcohols, thiols, and amines. Good functional group tolerance was demonstrated. The scale-up reaction and one-pot synthesis were also successfully performed.

Decarboxylative C(sp3)?O Cross-Coupling

Alkyl aryl ethers are an important class of compounds in medicinal and agricultural chemistry. Catalytic C(sp3)?O cross-coupling of alkyl electrophiles with phenols is an unexplored disconnection strategy to the synthesis of alkyl aryl ethers, with the potential to overcome some of the major limitations of existing methods such as C(sp2)?O cross-coupling and SN2 reactions. Reported here is a tandem photoredox and copper catalysis to achieve decarboxylative C(sp3)?O coupling of alkyl N-hydroxyphthalimide (NHPI) esters with phenols under mild reaction conditions. This method was used to synthesize a diverse set of alkyl aryl ethers using readily available alkyl carboxylic acids, including many natural products and drug molecules. Complementarity in scope and functional-group tolerance to existing methods was demonstrated.