102832-01-9

Upstream product

• 102831-99-2 (4S)-1-(tert-Butyldimethylsilyl)-4-<(1R)-1-<((4S)-4-ethyl-2-thioxo-1,3-thiazolidin-3-yl)carbonyl>ethyl>azetidin-2-one 
• 20194-18-7 sodium phenyl-methanolate 
• 187237-26-9 3-[(2R)-2-((4S)-1-tert-butyldimethylsilyl-2-oxoazetidin-4-yl)propionyl]-spiro[2,3-dihydro-4H-1,3-benzoxazin-2,1'-((2'R,5'S)-2'-isopropyl-5'-methylcyclohexane)]-4-one 
• 100-51-6 benzyl alcohol 
• 102831-94-7 (4S)-4-<(1R)-1-<((4S)-4-Ethyl-2-thioxo-1,3-thiazolidin-3-yl)carbonyl>ethyl>azetidin-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 90822-23-4 (3S,4R)-3-<(1R)-1-hydroxyethyl>-4-<(1R)-1-methyl-3-p-nitrobenzyloxycarbonyl-2-oxopropyl>-2-azetidin-2-one 
• 93576-40-0 (3S,4R)-1-(tert-Butyldimethylsilyl)-3-<(1R)-1-hydroxyethyl>-4-<(1R)-1-methyl-3-(p-nitrobenzyloxycarbonyl)-2-oxopropyl>azetidin-2-one 

Relevant academic research and scientific papers

A facile synthesis of (4S)-4-[(1R)-1-carboxyethyl]-1-(tert-butyldimethylsilyl)azetidin-2-one : A key intermediate of 1-β-methylcarbapenems

Titanium enolate-mediated aldol-type reaction of the chiral N-propionyl-1,3-benzoxazinone 4 with 4-acetoxyazetidin-2-one (5) gave the 2-(2-oxoazetidin-4-yl)propionic acid derivative 6 in high yield with high selectivity, which was transformed into (4S)-4-[(1R)-1-carboxyethyl]-1-(tert-butyldimethylsilyl)azetidin-2-one (3), a key intermediate of 1-β-methylcarbapenems 1.