10284-97-6

Upstream product

• 858445-43-9 3-phenylpropynal oxime 
• 2579-22-8 Phenylpropargyl aldehyde 
• 935-02-4 3-Phenyl-2-propynonitrile 

Downstream Products

• 24654-33-9 3-phenylethynyl-[1,2,4]oxadiazole 
• 24654-36-2 4-[1,2,4]oxadiazol-3-ylethynyl-aniline 
• 24654-34-0 3-(2-nitro-phenylethynyl)-[1,2,4]oxadiazole 
• 24654-35-1 3-(4-nitro-phenylethynyl)-[1,2,4]oxadiazole 
• 24654-37-3 3-(4-chloro-phenylethynyl)-[1,2,4]oxadiazole 

Relevant academic research and scientific papers

A cascade process for directly converting nitriles (RCN) to cyanamides (RNHCN) via SO2F2-activated Tiemann rearrangement

A simple, mild and practical process for the direct conversion of nitriles to cyanamides was newly discovered and exhibited a wide substrate scope as well as great functional group-tolerability (36 examples). In this efficient strategy, the in situ generated amidoximes obtained from the reaction of nitriles with hydroxylamine subsequently underwent Tiemann rearrangement, producing the corresponding cyanamides with great isolated yields under SO2F2. Additionally, the control experiments reportedly shed light on the tentative mechanism involved in the formation and elimination of the key intermediate: a sulfonyl ester.

SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)

A simple, mild and practical cascade process for the direct conversion of aldehydes to cyanamides was developed featuring a wide substrate scope and great functional group tolerability. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable cyanamides in a pot, atom, and step-economical manner with a green nitrogen source. This protocol will serve as a robust tool for the installation of the cyanamide moiety in various complicated molecules.