102851-66-1

Basic information

• Product Name: N-ethyl-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine
• Synonyms: N-ethyl-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine
• CAS NO: 102851-66-1
• Molecular Weight: 243.733
• Mol File: 102851-66-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-ethyl-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-ethyl-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine(102851-66-1)
• EPA Substance Registry System: N-ethyl-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine(102851-66-1)

Safety Data

• Hazardous Substances Data: 102851-66-1(Hazardous Substances Data)

Upstream product

• 93983-13-2 2-chloro-3,4-dimethoxybenzyl alcohol 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 41122-35-4 (E)-2-chloro-3,4-dimethoxy-1-(2-nitrovinyl)benzene 
• 7537-07-7 2-(2-chloro-3,4-dimethoxyphenyl)acetonitrile 
• 93983-14-3 2-chloro-3,4-dimethoxybenzyl chloride 
• 102851-64-9 2-chlorohomoveratrylacetamide 

Downstream Products

• 102851-72-9 N-ethyl-2-chlorodopamine 

Relevant articles and documents

Synthesis and Renal Vasodilator Activity of 2-Chlorodopamine and N-Substituted Derivatives

A four-step synthesis of 2-chlorodopamine (2b) is presented as well as methods for the syntheses of the N-methyl, ethyl, and n-propyl analogues (2c-e).Compounds 2b and 2c were essentially equipotent to dopamine for increasing renal blood flow in anesthesized dogs that had been treated with the α-adrenergic antagonist phenoxybenzamine.The increases in renal blood flow were blocked by the DA1 antagonist (R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine.Compounds 2d and 2e were significantly less potent than dopamine in the same model; the increases in renal blood flow were attenuated by propanolol and blocked by a combination of propanolol and (R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine.The significance of an o-chloro substituent on dopamine analogues for the activation of the DA1 receptor is briefly discussed.