41122-35-4

Basic information

• Product Name: TRANS-2-CHLORO-3 4-DIMETHOXY-B-NITROSTY&
• Synonyms: TRANS-2-CHLORO-3 4-DIMETHOXY-B-NITROSTY&;2-CHLORO-3,4-DIMETHOXY-TRANS-BETA-NITRO&;trans-2-chloro-3,4-dimethoxy-β-nitrostyrene;2-CHLORO-3,4-DIMETHOXY-BETA-NITROSTYRENE;1,2-Dimethoxy-3-chloro-4-(2-nitrovinyl)benzene, 2-(2-Chloro-3,4-dimethoxyphenyl)nitroethene
• CAS NO: 41122-35-4
• Molecular Formula: C₁₀H₁₀ClNO₄
• Molecular Weight: 243.645
• Mol File: 41122-35-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 89-93 °C(lit.)
• Boiling Point: 374.8°C at 760 mmHg
• Flash Point: 180.5°C
• Appearance: /
• Density: 1.305g/cm³
• Vapor Pressure: 1.75E-05mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: TRANS-2-CHLORO-3 4-DIMETHOXY-B-NITROSTY&(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-2-CHLORO-3 4-DIMETHOXY-B-NITROSTY&(41122-35-4)
• EPA Substance Registry System: TRANS-2-CHLORO-3 4-DIMETHOXY-B-NITROSTY&(41122-35-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 41122-35-4(Hazardous Substances Data)

Usage

Uses

2-Chloro-3,4-dimethoxy-β-nitrostyrene is an intermediate in the synthesis of high affinity D1 dopamine receptor ligand.

InChI:InChI=1/C10H10ClNO4/c1-15-8-4-3-7(5-6-12(13)14)9(11)10(8)16-2/h3-6H,1-2H3/b6-5+

Upstream product

• 75-52-5 nitromethane 
• 5417-17-4 2-chloro-3,4-dimethoxybenzaldehyde 
• 75-05-8 acetonitrile 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 621-59-0 isovanillin 
• 37687-57-3 2-chloro-3-hydroxy-4-methoxybenzaldehyde 

Downstream Products

• 46274-24-2 (5-chloro-3,4-dimethoxyphenyl)ethylamine 
• 1429438-71-0 5-chloro-6,7-bis((4-methoxybenzyl)oxy)-2-(2-(pyrrolidin-1-yl)ethyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1429438-70-9 5-chloro-6,7-bis((4-methoxybenzyl)oxy)-3,4-dihydroisoquinolin-1(2H)-one 
• 1429438-69-6 5-chloro-6,7-dihydroxy-3,4-dihydroisoquinolin-1(2H)-one 
• 1429438-68-5 ethyl 2-chloro-3,4-dimethoxyphenylethylcarbamate 
• 67287-36-9 2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 
• 102851-73-0 N-propyl-2-chlorodopamine 
• 102851-72-9 N-ethyl-2-chlorodopamine 
• 102851-71-8 N-methyl-2-chlorodopamine 
• 102851-70-7 2-chlorodopamine 
• 99318-58-8 N-(2-chlorohomoveratryl)propanamide 
• 102851-64-9 2-chlorohomoveratrylacetamide 
• 102851-63-8 (2-chlorohomoveratryl)formamide 
• 99318-59-9 N-(n-propyl)-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 

Relevant articles and documents

Chemoselective zinc/HCl reduction of halogenated β-nitrostyrenes: Synthesis of halogenated dopamine analogues

A detailed account regarding the synthesis of 2- and 5-halogenated dopamine is given. The key step is a chemoselective reduction of a nitrostyrene by Zn/HCl at 0 °C. These conditions represent a simple, low-cost alternative to reduction by water-sensitive hydride donors and two-step procedures. Under these conditions, aryl fluoride, chloride, and bromide groups are stable. However, iodine undergoes significant reductive dehalogenation.

Solid oral preparation containing a pyrrolidine derivative with a catechol group

An oral solid preparation comprising an organic acid or its salt and a catechol compound. The catechol compound is, for example, a pyrrolidine derivative having a catechol group of the following general formula (I). It exhibits an improved absorbability in vivo. STR1

6-HALO-3-LOWER ALKYL-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES

6-Halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures have a lower alkyl substituted at the 3 or N-position have potent and often specific anti-Parkinsonism activity by means of their central dopaminergic effect. The lead compound of the series is 6-chloro-3-methyl-1-phenyl-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin e as the base or its salts such as the hydrochloride, hydrobromide or methane sulfonate.