102877-53-2

Usage

Preparation

Preparation by nitration of 2-hydroxy-4-methoxyaceto-phenone (paeonol) with nitric acid (d = 1.42) in acetic acid (47%).

Upstream product

• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 56923-42-3 bis-(5-acetyl-4-hydroxy-2-methoxy-phenyl)-sulfide 
• 829-20-9 2',4'-dimethoxyacetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 

Downstream Products

• 93483-92-2 1-(5-amino-2-hydroxy-4-methoxyphenyl)ethanone 
• 109729-22-8 2'-hydroxy-4'-methoxy-3,4-methylenedioxy-5'-nitro-trans-chalcone 
• 134701-17-0 4-Methoxy-benzoic acid 2-acetyl-5-methoxy-4-nitro-phenyl ester 
• 134700-89-3 1-(2-Hydroxy-4-methoxy-5-nitro-phenyl)-3-phenyl-propane-1,3-dione 
• 134700-96-2 1-(2-Hydroxy-4-methoxy-5-nitro-phenyl)-3-(4-methoxy-phenyl)-propane-1,3-dione 
• 134701-04-5 4-(2-Hydroxy-4-methoxy-5-nitro-phenyl)-6-phenyl-pyrimidin-2-ol 
• 134701-11-4 4-(2-Hydroxy-4-methoxy-5-nitro-phenyl)-6-(4-methoxy-phenyl)-pyrimidin-2-ol 
• 103796-24-3 N-(5-acetyl-4-hydroxy-2-methoxyphenyl)acetamide 

Relevant academic research and scientific papers

Synthesis of novel 3/5(3,5)-(di)nitropaeonol hydrazone derivatives as nematicidal agents

Eighteen novel 3/5(3,5)-(di)nitropaeonol hydrazone derivatives were prepared, and their structures well characterized by 1H NMR, HRMS, and mp. Due to the steric hindrance, the substituents on the C = N double bond of all hydrazine compounds (ex

Preparation method of 5-nitropaeonol and 5-nitropaeonol hydrazone

The invention discloses a preparation method of 5-nitropaeonol and 5-nitropaeonol hydrazone. The method comprises the following steps: S1, carrying out nitration by using paeonol and concentrated nitric acid as raw materials and glacial acetic acid as a s

Paeonol derivative as well as preparation method, preparation and application thereof

The invention discloses a paeonol derivative and a preparation method, a preparation and an application thereof, and relates to the technical field of anti-inflammatory drug development. The paeonol derivative disclosed by the invention is simple in prepa

Paeonol hydrazone derivative as well as preparation method and application thereof and insecticide

The invention relates to a paeonol hydrazone derivative, a preparation method and application thereof, and an insecticide, and belongs to the technical field of botanical pesticides. The paeonol hydrazone derivative has a structure shown as a formula I; in the formula I, X is hydrogen, Y is nitro or X is nitro, Y is hydrogen or X, Y is nitro or X and Y are hydrogen at the same time, and Y is hydrogen at the same time; R1, R2 and R3 are respectively and independently selected from one of hydrogen and R4; and R4 is F, Cl, Br, nitro or alkyl. According to the paeonol hydrazone derivative, the final corrected death rate measured by adopting a small-leaf dish addition method under the concentration of 1mg/mL can reach 40% or above and can reach 70% or above to the maximum, the effect of preventing and treating the grassland spodoptera litura is remarkable, and the paeonol hydrazone derivative can be used as a new drug variety for preparing botanical insecticides.

Paeonol acylhydrazone derivative, preparation method and application thereof and insecticide

The invention relates to a paeonol acylhydrazone derivative, a preparation method and application thereof and an insecticide, and belongs to the technical field of insecticides. The paeonol acylhydrazone derivative has a structure shown as a formula I, in

Chalcone and flavone derivatives adopted as aurora kinase inhibitor

The present invention relates to design and synthesis of a class of chalcone and flavone derivatives represented by formulas I (I-1 and I-2) and II (II-1 and II-2), and inhibition effects of the derivatives on aurora kinase A. According to the present inv

COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES

This invention provides novel compounds of formulae (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein the substituents are as defined in the specification. The present invention also relates to the novel compounds for use as a medicine, more in particular for the prevention or treatment of amyloid-related diseases, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, disorders characterized by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such amyloid-related diseases. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.