116265-99-7

Basic information

• Product Name: 1-(5-chloro-2-hydroxy-4-methoxyphenyl)ethanone
• Synonyms: 1-(5-chloro-2-hydroxy-4-methoxyphenyl)ethanone
• CAS NO: 116265-99-7
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.62
• Mol File: 116265-99-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 154–155°C
• Boiling Point: 347.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.291±0.06 g/cm3(Predicted)
• PKA: 9.36±0.23(Predicted)
• CAS DataBase Reference: 1-(5-chloro-2-hydroxy-4-methoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-chloro-2-hydroxy-4-methoxyphenyl)ethanone(116265-99-7)
• EPA Substance Registry System: 1-(5-chloro-2-hydroxy-4-methoxyphenyl)ethanone(116265-99-7)

Safety Data

• Hazardous Substances Data: 116265-99-7(Hazardous Substances Data)

Usage

Preparation

Preparation by diazotization of 5-amino-2-hydroxy-4- methoxyacetophenone and replacement of diazonium group by chlorine (Sandmeyer reaction).

Upstream product

• 90110-32-0 1-(5-chloro-2,4-dihydroxyphenyl)ethan-1-one 
• 77-78-1 dimethyl sulfate 
• 95-88-5 4-Chlororesorcinol 
• 863116-39-6 2-hydroxy-3-iodo-4-methoxy-5-chloro-acetophenone 
• 829-20-9 2',4'-dimethoxyacetophenone 
• 102877-53-2 1-(2-hydroxy-4-methoxy-5-nitrophenyl)ethanone 
• 151-10-0 1,3-Dimethoxybenzene 
• 7051-13-0 1-chloro-2,4-dimethoxybenzene 
• 75-36-5 acetyl chloride 
• 93483-92-2 1-(5-amino-2-hydroxy-4-methoxyphenyl)ethanone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 

Downstream Products

• 1106539-59-6 (2-Acetyl-4-chloro-5-methoxy-phenoxy)-acetic acid ethyl ester 

Relevant articles and documents

Paeonol acylhydrazone derivative, preparation method and application thereof and insecticide

The invention relates to a paeonol acylhydrazone derivative, a preparation method and application thereof and an insecticide, and belongs to the technical field of insecticides. The paeonol acylhydrazone derivative has a structure shown as a formula I, in

BENZOFURAN AND BENZOTHIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES

The present invention relates to compounds of formula I wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

Studies on uricosuric diuretics. II. Substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids

A series of substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids were synthesized and evaluated for uricosuric and diuretic activities in rats. Many of the benzisoxazole derivatives showed uricosuric and only weak diuretic activities, whereas the benzoxazoles exhibited potent diuretic activities with little affecting urate excretion. Among these compounds, 5-chloro-7,8-dihydro-3-phenylfuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid (AA-193) was found to be a potent uricosuric agent without diuretic activity and was selected for further development.