102879-31-2

Upstream product

• 1795-98-8 rac-phenylalaninol 
• 15028-44-1 DL-phenylalanine methyl ester 
• 63-91-2 L-phenylalanine 
• 59830-60-3 benzyl (1S)-(1-formyl-2-phenylethyl)carbamate 
• 5241-58-7 L-Phenylalanine amide 

Downstream Products

• 74134-77-3 2,5-dibenzylpyrazine 
• 862254-42-0 C₁₀H₁₁N₃*ClH 
• 95713-60-3 L-Phe-L-FDAA 
• 3182-95-4 L-Phenylalaninol 

Relevant academic research and scientific papers

Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers

The formation of advanced glycation end-products (AGE) as a result of the action of reducing sugars on host macromolecules plays a role in increased morbidity of diabetic patients. There are currently no clinically available therapeutics for the preventio

A new method for the synthesis of symmetrical disubstituted pyrazines

Through the self-condensation of α-amino aldehydes, the synthesis of symmetrical disubstituted pyrazines was achieved in a three-step one-pot reaction. The α-amino aldehydes were easily obtained by treating methyl esters of natural α-amino acids with diisobutylaluminium hydride.

Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors

Calpain inhibitors which are derived from piperidine carboxamides in the P2 region were prepared and evaluated for μ-calpain inhibition. In particular, the keto amides 11f and 11j have K(i) of 30 and 9 nM and display a more than 100-fold selectivity over the closely related cysteine protease cathepsin B. Furthermore, these compounds inhibit NMDA induced convulsions in mice indicating that calpain inhibition in brain results in some anticonvulsive properties. (C) 2000 Elsevier Science Ltd.

Novel peptidase inhibitors

This invention relates to activated electrophilic ketone analogs of certain peptidase substrates which are useful in inhibiting serine-, carboxylic acid-and metallo-proteolytic enzymes, the inhibition of which will have useful physiological consequences i

Tripeptide compounds having a nitrogenous polycyclic structure

The invention relates to the compounds of general formula: STR1 in which: X denotes either an oxygen atom, or two hydrogen atoms; Y denotes either a hydrogen atom, or a hydroxyl group; or Y denotes an amino group on condition that X denotes two hydrogen atoms; R denotes a hydrogen atom, or a straight- or branched-chain alkyl group having 1 to 6 carbon atoms, optionally substituted with one or more hydroxy, amino, mercapto, methylthio or carboxy groups, or aryl groups such as phenyl, pyridyl or thienyl; STR2 denotes a polycyclic nitrogenous structure; their enantiomers, epimers and diastereoisomers, as well as their addition salts with a pharmaceutically acceptable acid or base.

Ru(III) Catalysed Oxidation of Aminoacids by N-Bromosuccinimide in Aqueous Acetic Acid: A Kinetic Study

Kinetics of Ru(III) catalysed oxidation of glycine (GLy), α-alanine (α-ala), β-alanine (β-ala) leucine (Leu), phenyl glycine (Ph-gly) and phenyl alanine (Ph-ala) by N-bromosuccinimide in the presence of mercuric acetate have been studied in aqueous acetic acid medium in the presence of sulphuric acid.The oxidation products were identified as corresponding aldehydes, ammonia, and carbondioxide.The order of was found to be unity both in catalysed as well as uncatalysed reactions.However the first order of changed from unity to a fractional one in the presence of Ru(III).The applicability of Taft's equation was tested.On the basis of kinetic features the probable mechanisms were discussed and individual rate parameters evaluated.