102879-31-2Relevant articles and documents
Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers
Furlani, Robert E.,Richardson, Mike A.,Podell, Brendan K.,Ackart, David F.,Haugen, Jessica D.,Melander, Roberta J.,Basaraba, Randall J.,Melander, Christian
, p. 4820 - 4823 (2015)
The formation of advanced glycation end-products (AGE) as a result of the action of reducing sugars on host macromolecules plays a role in increased morbidity of diabetic patients. There are currently no clinically available therapeutics for the preventio
Observations concerning the existence and reactivity of free α-amino aldehydes as chemical intermediates: Evidence for epimerization-free adduct formation with various nucleophiles [11]
Myers, Andrew G.,Kung, Daniel W.,Zhong, Boyu
, p. 3236 - 3237 (2007/10/03)
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Novel peptidase inhibitors
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, (2008/06/13)
This invention relates to activated electrophilic ketone analogs of certain peptidase substrates which are useful in inhibiting serine-, carboxylic acid-and metallo-proteolytic enzymes, the inhibition of which will have useful physiological consequences i