102882-04-2

Upstream product

• 99903-37-4 methyl <1-phenyl-2-(E)-butenyl>acetate 
• 67-56-1 methanol 
• 5703-52-6 3-phenylhexanoic acid 
• 108-86-1 bromobenzene 
• 21188-58-9 methyl 3-hydroxyhexanoate 
• 100017-26-3 (R)-(Z)-3-acetoxy-1-phenyl-1-butene 
• 100017-28-5 (R)-(Z)-1-acetoxy-1-phenyl-2-butene 
• 17488-65-2 (R)-(Z)-3-hydroxy-1-phenyl-1-butene 
• 88057-05-0 <1-phenyl-2-(E)-butenyl>malonate 
• 100017-30-9 (R)-(Z)-1-hydroxy-1-phenyl-2-butene 
• 82045-04-3 (rac)-(E)-2-acetoxy-4-phenylbut-3-ene 
• 51801-01-5 (E)-1-acetoxy-1-phenyl-2-butene 
• 52755-39-2 (2E)-1-phenylbut-2-en-1-ol 
• 36004-04-3 ethyl (E)-1-phenylbut-1-en-3-ol 

Downstream Products

• 1018075-26-7 3-(4-chlorosulfonyl-phenyl)hexanoic methyl ester 

Relevant academic research and scientific papers

Electrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides

As alcohols are ubiquitous throughout chemical science, this functional group represents a highly attractive starting material for forging new C-C bonds. Here, we demonstrate that the combination of anodic preparation of the alkoxy triphenylphosphonium ion and nickel-catalyzed cathodic reductive cross-coupling provides an efficient method to construct C(sp2)-C(sp3) bonds, in which free alcohols and aryl bromides - both readily available chemicals - can be directly used as coupling partners. This nickel-catalyzed paired electrolysis reaction features a broad substrate scope bearing a wide gamut of functionalities, which was illustrated by the late-stage arylation of several structurally complex natural products and pharmaceuticals.

Disulfide symmetric dimers as stable pre-hapten forms for bioconjugation: A strategy to prepare immunoreagents for the detection of sulfophenyl carboxylate residues in environmental samples

A convenient, generic synthesis of bioconjugates from haptens with a thiol group has been established. The corresponding haptens are synthesized as stable symmetric dimmers through a disulfide bond that is reduced immediately before conjugation with the a

Stereo- and Regiochemistry in Palladium-Catalyzed Nucleophilic Substitution of Optically Active (E)- and (Z)-Allyl Acetates

Optically acive (E)- and (Z)-allyl acetates, 3-acetoxy-1-phenyl-1-butene (1) and its regioisomer, 1-acetoxy-1-phenyl-3-butene (2), were allowed to react with sodium dimethyl malonate, sodium acetylacetonate, and sodium methyl acetoacetate in the presence of a palladium catalyst.The reaction of (E)-acetates proceeded with retention of configuration and that of (Z)-acetates proceeded with inversion accompanied by geometrical isomerization from Z to E.The stereochemistry observed in the reaction with phenylzinc bromide was opposite to that with the soft nucleophiles.