1029033-62-2

Upstream product

• 5162-44-7 1-bromo-4-butene 
• 104-86-9 4-chlorobenzylamine 

Downstream Products

• 1029033-65-5 dimethyl [(but-3-enyl)(4-chlorobenzyl)amino](2-vinylphenyl)methylphosphonate 
• 1591714-06-5 C₁₈H₂₂ClNO₃ 

Relevant academic research and scientific papers

Quinim: A New Ligand Scaffold Enables Nickel-Catalyzed Enantioselective Synthesis of α-Alkylated ?-Lactam

Herein, we report a nickel-catalyzed reductive cross-coupling reaction of easily accessible 3-butenyl carbamoyl chloride with primary alkyl iodide to access the chiral α-alkylated pyrrolidinone with broad substrate scope and high enantiomeric excess. The current art of synthesis still remains challenging on the enantioselective α-monoalkylation of pyrrolidinones. The newly designed chiral 8-quinoline imidazoline ligand (Quinim) is crucial for maintaining the reactivity and enantioselectivity to ensure the reductive cyclization of monosubstituted alkenes for unprecedented synthesis of chiral non-aromatic heterocycles.

Cs2CO3-Promoted Direct N-Alkylation: Highly Chemoselective Synthesis of N-Alkylated Benzylamines and Anilines

Herein is described an efficient and chemoselective method for the synthesis of diversely substituted secondary amines in yields up to 98 %. Direct mono-N-alkylation of primary benzylamines and anilines with a wide range of alkyl halides is promoted by a cesium base in the absence of any additive or catalyst. The basicity and solubility of cesium carbonate in anhydrous N,N-dimethylformamide not only enables mono-N-alkylation of primary amines but also suppresses undesired dialkylation of the desired amines.

Ring-closing metathesis and ring-closing metathesis-isomerisation approach to 1-phosphonylated 2-benzazocines

An RCM strategy has been developed for the synthesis of phosphonylated benzazocines and their corresponding isomerised analogues. The aminophosphonate precursors were obtained by a one-pot three-component condensation in moderate yield.