1029033-64-4Relevant academic research and scientific papers
Quinim: A New Ligand Scaffold Enables Nickel-Catalyzed Enantioselective Synthesis of α-Alkylated ?-Lactam
Chen, Yifeng,Qu, Jingping,Wu, Xianqing
supporting information, p. 15654 - 15660 (2020/10/18)
Herein, we report a nickel-catalyzed reductive cross-coupling reaction of easily accessible 3-butenyl carbamoyl chloride with primary alkyl iodide to access the chiral α-alkylated pyrrolidinone with broad substrate scope and high enantiomeric excess. The current art of synthesis still remains challenging on the enantioselective α-monoalkylation of pyrrolidinones. The newly designed chiral 8-quinoline imidazoline ligand (Quinim) is crucial for maintaining the reactivity and enantioselectivity to ensure the reductive cyclization of monosubstituted alkenes for unprecedented synthesis of chiral non-aromatic heterocycles.
Ring-closing metathesis and ring-closing metathesis-isomerisation approach to 1-phosphonylated 2-benzazocines
Dieltiens, Nicolai,Stevens, Christian V.,Masschelein, Kurt,Hennebel, Geert,Van der Jeught, Sarah
, p. 4295 - 4303 (2008/09/19)
An RCM strategy has been developed for the synthesis of phosphonylated benzazocines and their corresponding isomerised analogues. The aminophosphonate precursors were obtained by a one-pot three-component condensation in moderate yield.
