1029062-63-2Relevant academic research and scientific papers
Design, synthesis and docking studies of benzimidazole derivatives as potential EGFR inhibitors
Celik, ?smail,Ayhan-K?lc?gil, Gülgün,Guven, Berna,Kara, Zümra,Gurkan-Alp, A. Selen,Karayel, Arzu,Onay-Besikci, Arzu
, p. 240 - 249 (2019/04/25)
In this study, a series of benzimidazoles bearing thiosemicarbazide chain or triazole and thiadiazole rings were designed and synthesized. Crystal and molecular structure of the compound 5c has been characterized by single crystal X-ray crystallographic a
Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol-2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class
Kus, Canan,Ayhan-Kilcigil, Guelguen,Oezbey, Sueheyla,Kaynak, F. Betuel,Kaya, Melek,Coban, Tuelay,Can-Eke, Benay
, p. 4294 - 4303 (2008/09/20)
Some novel 1-methyl-4-(2-(2-substitutedphenyl-1H-benzimidazol-1-yl)acetyl)thiosemicarbazides (16a-20a), 5-[(2-(substitutedphenyl)-1H-benzimidazol-1-yl)methyl]-N-methyl-1,3,4-thiadiazol-2-amines (17b-20b), and 5-[(2-(substitutedphenyl)-1H-benzimidazol-1-yl)methyl-4-methyl-2H-1,2,4-triazole-3(4H)-thiones (16c-20c) were synthesized and tested for antioxidant properties by using various in vitro systems. Compounds 16a-20a were found to be a good scavenger of DPPH radical (IC50, 26 μM; IC50, 30 μM; IC50, 43 μM; IC50, 55 μM; IC50, 74 μM, respectively) when compared to BHT (IC50, 54 μM). Noteworthy results could not be found on superoxide radical. Compound 19b, which is the most active derivative inhibited slightly lipid peroxidation (28%) at 10-3 M concentration. Compound 17c inhibited the microsomal ethoxyresorufin O-deethylase (EROD) activity with an IC50 = 4.5 × 10-4 M which is similarly better than the specific inhibitor caffeine IC50 = 5.2 × 10-4 M.
