10292-61-2

Basic information

• Product Name: 4-CYCLOPROPYLPHENOL
• Synonyms: AKOS BAR-1183;4-CYCLOPROPYLPHENOL;(4-Hydroxyphenyl)cyclopropane;4-Cyclopropylphenol 98%;4-Cyclopropylphenol98%;Phenol, p-cyclopropyl-
• CAS NO: 10292-61-2
• Molecular Formula: C₉H₁₀O
• Molecular Weight: 134.18
• Mol File: 10292-61-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 57-58℃
• Boiling Point: 248.2±19.0℃ (760 Torr)
• Flash Point: 119.8±11.0℃
• Appearance: /
• Density: 1.158±0.06 g/cm3 (20 ºC 760 Torr)
• Refractive Index: 1.5618 (589.3 nm 20℃)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.05±0.13(Predicted)
• CAS DataBase Reference: 4-CYCLOPROPYLPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYCLOPROPYLPHENOL(10292-61-2)
• EPA Substance Registry System: 4-CYCLOPROPYLPHENOL(10292-61-2)

Safety Data

• Hazardous Substances Data: 10292-61-2(Hazardous Substances Data)

Usage

General Description

4-Cyclopropylphenol is a chemical compound with the molecular formula C9H10O. It is a white solid that is insoluble in water but soluble in organic solvents. 4-CYCLOPROPYLPHENOL is commonly used in the production of pharmaceuticals, dyes, and other organic compounds. It is also used as a building block for the synthesis of various organic substances, particularly those with biological or medicinal applications. Additionally, 4-cyclopropylphenol has been studied for its potential antimicrobial and antifungal properties, making it a valuable chemical in the field of medicine and research.

InChI:InChI=1S/C9H10O/c10-9-5-3-8(4-6-9)7-1-2-7/h3-7,10H,1-2H2

Upstream product

• 501-92-8 4-(prop-2-enyl)phenol 
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• 106-41-2 4-bromo-phenol 
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Relevant articles and documents

Lewis Base-Promoted Ring-Opening 1,3-Dioxygenation of Unactivated Cyclopropanes Using a Hypervalent Iodine Reagent

A facile and effective system has been developed for the regio- and chemoselective ring-opening/electrophilic functionalization of cyclopropanes through C?C bond activation by [bis(trifluoroacetoxy)iodo]benzene with the aid of the Lewis basic promoter p-toluenesulfonamide. The p-toluenesulfonamide-promoted system works well for a wide range of cyclopropanes, resulting in the formation of 1,3-diol products in good yields and regioselectivity.

Direct hydroxylation of benzene and aromatics with H2O2 catalyzed by a self-assembled iron complex: Evidence for a metal-based mechanism

An iminopyridine Fe(ii) complex, easily prepared in situ by self-assembly of cheap and commercially available starting materials (2-picolylaldehyde, 2-picolylamine, and Fe(OTf)2 in a 2 : 2 : 1 ratio), is shown to be an effective catalyst for the direct hydroxylation of aromatic rings with H2O2 under mild conditions. This catalyst shows a marked preference for aromatic ring hydroxylation over lateral chain oxidation, both in intramolecular and intermolecular competitions, as long as the arene is not too electron poor. The selectivity pattern of the reaction closely matches that of electrophilic aromatic substitutions, with phenol yields and positions dictated by the nature of the ring substituent (electron-donating or electron-withdrawing, ortho-para or meta-orienting). The oxidation mechanism has been investigated in detail, and the sum of the accumulated pieces of evidence, ranging from KIE to the use of radical scavengers, from substituent effects on intermolecular and intramolecular selectivity to rearrangement experiments, points to the predominance of a metal-based SEAr pathway, without a significant involvement of free diffusing radical pathways.

HCV POLYMERASE INHIBITORS

The invention provides compounds of the formula:(I) wherein B is a nucleobase selected from the groups (a) to (d) and the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C virus infection, and related aspects.