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2-Benzyl-5-(((2,3-difluorophenyl)thio)methyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol is a complex organic compound with a molecular formula of C21H15F2N4OS. It features a triazolo[1,5-a]pyrimidin-7-ol core, which is a heterocyclic ring system containing nitrogen and oxygen atoms. The molecule is further characterized by a benzyl group attached at the 2-position, a difluorophenylthiomethyl group at the 5-position, and a hydroxyl group at the 7-position. 2-benzyl-5-(((2,3-difluorophenyl)thio)methyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol is of interest in medicinal chemistry, potentially for its biological activities, and is a testament to the diversity and complexity of chemical structures that can be synthesized for various applications.

1029520-80-6

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1029520-80-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1029520-80-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,9,5,2 and 0 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1029520-80:
(9*1)+(8*0)+(7*2)+(6*9)+(5*5)+(4*2)+(3*0)+(2*8)+(1*0)=126
126 % 10 = 6
So 1029520-80-6 is a valid CAS Registry Number.

1029520-80-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-benzyl-5-(((2,3-difluorophenyl)thio)methyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

1.2 Other means of identification

Product number -
Other names 2-benzyl-5-(2,3-difluorophenylsulfanylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1029520-80-6 SDS

1029520-80-6Downstream Products

1029520-80-6Relevant academic research and scientific papers

The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists

Porter, David W.,Bradley, Michelle,Brown, Zarin,Canova, Riccardo,Charlton, Steven,Cox, Brian,Hunt, Peter,Kolarik, David,Lewis, Sarah,O'Connor, Des,Reilly, John,Spanka, Carsten,Tedaldi, Lauren,Watson, Simon J.,Wermuth, Roland,Press, Neil J.

, p. 72 - 76 (2014/01/17)

A hit-to-lead optimisation programme was carried out on the Novartis archive screening hit, pyrazolopyrimidine 2-methyl-5-((phenylthio)methyl) pyrazolo[1,5-a]pyrimidin-7-ol 1, resulting in the discovery of CXCR2 receptor antagonist 2-benzyl-5-(((2,3-difluorophenyl)thio)methyl)-[1,2,4]triazolo[1,5-a] pyrimidin-7-ol 14. The SAR was investigated by systematic variation of the pendant thiol, alkyl and pyrimidinol groups. Replacement of the pyrazolopyrimidine core with a triazolo alternative led to a dual series of antagonists with favourable biological and pharmacokinetic properties.

5-SULFANYLMETHYL-[1,2,4] TRIAZOL[l,5-A] PYRIMIDIN-7-OL DERIVATIVES AS CXCR2 ANTAGONISTS

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Page/Page column 16, (2008/12/05)

The present invention relates to compounds of formula (I) and the use of these compounds as pharmaceuticals, e.g. in preventing or treating a CXCR2 receptor mediated condition or disease.

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