130922-39-3

Usage

Uses

Used in Chemical Industry:
Benzenethiol, 2,3-difluoro(9CI) is used as a chemical intermediate for the synthesis of various compounds. Its unique structure with fluorine atoms allows for specific reactivity and properties that can be exploited in the production of specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, Benzenethiol, 2,3-difluoro(9CI) is utilized as a building block for the development of new drugs. The presence of fluorine atoms can influence the pharmacokinetics and pharmacodynamics of the resulting drug molecules, potentially leading to improved therapeutic effects or reduced side effects.

Upstream product

• 6418-38-8 2,3-difluorophenol 
• 1028843-09-5 dimethyl-thiocarbamic acid O-(2,3-difluoro-phenyl) ester 
• 1028843-10-8 dimethyl-thiocarbamic acid S-(2,3-difluoro-phenyl) ester 

Downstream Products

• 1028843-08-4 methyl 4-((2,3-difluorophenyl)thio)-3-oxobutanoate 
• 1029520-80-6 2-benzyl-5-(((2,3-difluorophenyl)thio)methyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol 
• 1029520-84-0 2-methyl-5-(2,3-difluorophenylsulfanylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol 
• 1029520-87-3 2-isopropyl-5-(2,3-difluorophenylsulfanylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol 
• 1029520-92-0 2-cyclohexyl-5-(2,3-difluorophenylsulfanylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol 
• 1029520-91-9 2-phenyl-5-(2,3-difluorophenylsulfanylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol 
• 1029520-90-8 2-phenethyl-5-(2,3-difluorophenylsulfanylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol 
• 1028842-47-8 5-(2,3-difluoro-phenylsulfanylmethyl)-2-furan-2-yl-pyrazolo[1,5-a]pyrimidin-7-ol 
• 1028842-42-3 5-(2,3-difluoro-phenylsulfanylmethyl)-2-pyridin-2-yl-pyrazolo[1,5-a]pyrimidin-7-ol 
• 1028842-58-1 5-(2,3-difluoro-phenylsulfanylmethyl)-2-(3-methyl-furan-2-yl)-pyrazolo[1,5-a]pyrimidin-7-ol 
• 1028842-76-3 2-(2,3-difluoro-phenylsulfanylmethyl)-7,8,9,10-tetrahydro-pyrimido[1,2-b]indazol-4-ol 
• 1028842-48-9 2-(2,3-difluoro-phenylsulfanylmethyl)-pyrimido[1,2-b]indazol-4-ol 
• 1028842-06-9 5-(2,3-difluoro-phenylsulfanylmethyl)-pyrazolo[1,5-a]pyrimidin-7-ol 
• 1028842-21-8 5-(2,3-difluoro-phenylsulfanylmethyl)-3-cyano-pyrazolo[1,5-a]pyrimidin-7-ol 

Relevant academic research and scientific papers

The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists

A hit-to-lead optimisation programme was carried out on the Novartis archive screening hit, pyrazolopyrimidine 2-methyl-5-((phenylthio)methyl) pyrazolo[1,5-a]pyrimidin-7-ol 1, resulting in the discovery of CXCR2 receptor antagonist 2-benzyl-5-(((2,3-difluorophenyl)thio)methyl)-[1,2,4]triazolo[1,5-a] pyrimidin-7-ol 14. The SAR was investigated by systematic variation of the pendant thiol, alkyl and pyrimidinol groups. Replacement of the pyrazolopyrimidine core with a triazolo alternative led to a dual series of antagonists with favourable biological and pharmacokinetic properties.

5-SULFANYLMETHYL-[1,2,4] TRIAZOL[l,5-A] PYRIMIDIN-7-OL DERIVATIVES AS CXCR2 ANTAGONISTS

The present invention relates to compounds of formula (I) and the use of these compounds as pharmaceuticals, e.g. in preventing or treating a CXCR2 receptor mediated condition or disease.

5-SULFANYLMETHYL-PYRAZOLO [1,5-A] PYRIMIDIN-7-OL DERIVATIVES AS CXCR2 ANTAGONISTS

The present invention relates to compounds of formula (I) and the use of these compounds as pharmaceuticals, e.g. in preventing or treating a CXCR2 receptor mediated condition or disease.