10296-76-1Relevant academic research and scientific papers
Comprehensive Synthesis of Substrates, Intermediates, and Products of the Sulfoglycolytic Embden-Meyerhoff-Parnas Pathway
Abayakoon, Palika,Epa, Ruwan,Petricevic, Marija,Bengt, Christopher,Mui, Janice W.-Y.,Van Der Peet, Phillip L.,Zhang, Yunyang,Lingford, James P.,White, Jonathan M.,Goddard-Borger, Ethan D.,Williams, Spencer J.
, p. 2901 - 2910 (2019)
Sulfoglycolysis is a metabolic pathway dedicated to the catabolism of the sulfosugar sulfoquinovose (SQ) into smaller organosulfur fragments. An estimated 10 billion tonnes of SQ fluxes through sulfoglycolysis pathways each year, making it a significant aspect of the biogeochemical sulfur cycle. Delineating the molecular details of sulfoglycolysis requires authentic samples of the various metabolites in these pathways. To this end, we have established chemical and chemoenzymatic methods for the synthesis of the key organosulfur metabolites sulfoquinovosylglycerol, SQ (also in 13C6-labeled form), sulfofructose, sulfofructose-1-phosphate, sulfolactaldehyde, and 2,3-dihydroxypropanesulfonate, as well as an improved route to the chromogenic sulfoquinovosidase substrate 4-nitrophenyl α-sulfoquinovoside.
Preparation method and application of organic sulfonic acid
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Paragraph 0063-0074; 0099-0102, (2021/11/21)
The invention relates to the technical field of fine chemicals, in particular to a preparation method and application of organic sulfonic acid. The preparation method of the organic sulfonic acid comprises the following specific steps: S1, preparing organic sulfonate; S2, reacting the organic sulfonate with a proton donor to obtain an organic sulfonic acid crude product; and S3, purifying the organic sulfonic acid crude product to obtain a finished product. The organic sulfonic acid obtained by the invention has the following advantages that (1) a gaseous proton provider is adopted, so that the production efficiency in the actual reaction process is improved while a polyhydroxy alkane sulfonic acid product with high reaction yield is obtained; (2) processing and purifying are performed by adopting enamel film evaporation and short-path molecular distillation equipment, and acidic byproducts and water in liquid components of reaction products are effectively separated to obtain a polyhydroxy alkane sulfonic acid finished product with the moisture content as low as 0.3%; and (3) recovery of hydrochloric acid can be realized while the polyhydroxy alkane sulfonic acid is obtained in the purification and separation process, and industrial mass production of the polyhydroxy alkane sulfonic acid is realized.
Arsenic-containing Ribofuranosides: Isolation from Brown Kelp Ecklonia radiata and Nuclear Magnetic Resonance Spectra
Edmonds, John S.,Francesconi, Kevin A.
, p. 2375 - 2382 (2007/10/02)
2-Hydroxy-3-sulphopropyl 5-deoxy-5-(dimethylarsinoyl)-β-ribofuranoside (1a) and 2,3-dihydroxypropyl 5-deoxy-5-(dimethylarsinoyl)-β-ribofuranoside (1b) have been isolated from the brown kelp Ecklonia radiata.Extraction of a second batch of Ecklonia yielded 3-'glycerophosphoryl'-2-hydroxy-1-propane (1c) together with compound (1a).These compounds were identified chiefly by n.m.r. spectroscopy.N.m.r. data for the related (2S)-3--2-hydroxypropyl hydrogen sulphate (1d), extracted from the giant clam Tridacna maxima, are presented also.
