1029649-75-9Relevant academic research and scientific papers
Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (Hsp90) molecular chaperone
Kung, Pei-Pei,Huang, Buwen,Zhang, Gang,Zhou, Joe Zhongxiang,Wang, Jeff,Digits, Jennifer A.,Skaptason, Judith,Yamazaki, Shinji,Neul, David,Zientek, Michael,Elleraas, Jeff,Mehta, Pramod,Yin, Min-Jean,Hickey, Michael J.,Gajiwala, Ketan S.,Rodgers, Caroline,Davies II, Jay F.,Gehring, Michael R.
, p. 499 - 503 (2010)
The discovery and optimization of potency and metabolic stability of a novel class of dihyroxyphenyl-isoindoline amides as Hsp90 inhibitors are presented. Optimization of a screening hit using structure-based design and modification of log D and chemical
