102976-62-5Relevant articles and documents
Synthesis and characterization benzimidazole ring by using O-phenylinediamine with different compounds and using mannich reaction for preparation of some derivatives
Kadhim, Abdullah Jawad
, p. 473 - 481 (2018)
The research includes synthesis and characterization Benzimidazole rings by using different compounds such as Urea, Thiourea and Carboxylic acid by reactant with O-phenylinediamine, then substitution hydrogen atom with present on nitrogen atom by reactant with primary and secondary amines according to Mannich reaction. Compounds was organized by using F.T.I.R and HNMR spectroscopy.
Chemical synthesis method for 2-hydroxybenzimidazole
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Paragraph 0012, (2019/02/26)
The invention discloses a chemical synthesis method for 2-hydroxybenzimidazole. The method comprises the following steps: S1, preparing raw materials and instruments, wherein the raw materials comprise sodium hydrogen sulfite, purified water, aldehyde, o-phenylenediamine, ethanol and TLC (Thin-Layer Chromatography) (spectrum tomography), and the instruments comprise an X4 microscopic melting pointapparatus, a thermometer, a nuclear magnetic resonance spectrometer, an infrared spectrometer and an elemental analyzer; and S2, synthesizing hydroxy sulfonate, namely dissolving 0.1083 mol of sodiumhydrogen sulfite into 14 mL of purified water, stirring for 30 minutes, adding 0.1063 mol of benzaldehyde, stirring and reacting for 0.15 hour, performing suction filtration, washing with 10 mL of purified water, and collecting the white solid a1. The benzaldehyde is reacted with the o-phenylenediamine, the reaction can be completed within 2 hours, the yield is 80% or higher, and due to the reaction between the intermediate hydroxy sulfonate and the o-phenylenediamine, the reaction time is maintained, so that the adhesion of the solid product is spherically dispersed, and the yield is improved.
Direct conversion of thiols to sulfonyl chlorides and sulfonamides
Bahrami, Kiumars,Khodaei, Mohammad M.,Soheilizad, Mehdi
supporting information; experimental part, p. 9287 - 9291 (2010/03/04)
(Chemical Equation Presented) H2O2 in combination with SOCl2 proved to be a highly reactive reagent for the direct oxidative conversion of thiol derivatives to the corresponding sulfonyl chlorides with high purity through oxidative chlorination. Upon reaction with amines, the corresponding sulfonamides were obtained in excellent yields and in very short reaction times.
