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540-67-0 Usage


Ethyl methyl ether (methoxyethane, IUPAC) is a colorless liquid that is soluble in water. Specific gravity is 0.70, which is lighter than water. It is highly flammable, with a flammable range of 2%–10.1% in air. Boiling point is 51°F (10°C), flash point is ?35°F (?37°C), and ignition temperature is 374°F (190°C). Vapor density is 2.07, which is heavier than air. In addition to flammability, ethyl methyl ether is an anesthetic and can form explosive peroxides as it ages. The four-digit UN identification number is 1039. The NFPA 704 designation is health 1, flammability 4, and reactivity 1. The primary use is in medicine as an anesthetic.

Chemical Properties

Different sources of media describe the Chemical Properties of 540-67-0 differently. You can refer to the following data:
1. Colorless liquid. Soluble in water; miscible with alcohol and ether.
2. Methyl ethyl ether is a colorless liquid or gas at room temperature.


Medicine (anesthetic).


ChEBI: An ether that is the methyl ether derivative of ethanol.

General Description

A clear colorless gas with a medicine-like odor. Flash point -35°F. Boiling point 52°F. Less dense than water. Vapors are heavier than air. Under prolonged exposure to fire or heat the containers may rupture violently and rocket.

Air & Water Reactions

Highly flammable. Soluble in water. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. A mixture of liquid air and diethyl ether exploded spontaneously, [MCA Case History 616(1960)].

Reactivity Profile

Ethers, such as ETHYL METHYL ETHER, can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.

Health Hazard

Vapors may cause dizziness or asphyxiation without warning. Some may be irritating if inhaled at high concentrations. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating and/or toxic gases.

Fire Hazard

EXTREMELY FLAMMABLE. Will be easily ignited by heat, sparks or flames. Will form explosive mixtures with air. Vapors from liquefied gas are initially heavier than air and spread along ground. CAUTION: Hydrogen (UN1049), Deuterium (UN1957), Hydrogen, refrigerated liquid (UN1966) and Methane (UN1971) are lighter than air and will rise. Hydrogen and Deuterium fires are difficult to detect since they burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.) Vapors may travel to source of ignition and flash back. Cylinders exposed to fire may vent and release flammable gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.

Safety Profile

Has anesthetic properties. A very dangerous fire and moderate explosion hazard when exposed to heat or flame; can react vigorously with oxidizing materials (e.g., air, O2). To fight fire, use alcohol foam, CO2, dry chemical. See also ETHERS.

Potential Exposure

Used as a medicine and anesthetic.


UN1039 Methyl ethyl ether or Ethyl methyl ether, Hazard Class: 2.1; Labels: 2.1-Flammable gas.

Purification Methods

Dry the ether with CaSO4, pass it through an alumina column (to remove peroxides), then fractionally distil it. [Beilstein 1 H 314, 1 I 158, 1 II 311, 1 III 1288, 1 IV 1314.]


May form explosive mixture with air. Incompatible, dangerous reaction with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.). Keep away from alkaline materials, strong acids (may be explosive), strong bases. May form explosive peroxides on standing.

Check Digit Verification of cas no

The CAS Registry Mumber 540-67-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 0 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 540-67:
60 % 10 = 0
So 540-67-0 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name methoxyethane

1.2 Other means of identification

Product number -
Other names Ethane, methoxy-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:540-67-0 SDS

540-67-0Relevant articles and documents

Four Isomers of +. Distinguished by Collisional Activation

Crow, Frank W.,Gross, Michael L.,Bursey, Maurice M.

, p. 309 - 311 (1981)

Collisional activation of the molecular ions of 1-propanol, 2-propanol and methyl ethyl ether, and of the m/z 60 ion from 1,2-dimethoxyethane provides evidence for four distinct forms of +..Collision induced decompositions may be explained either by simple cleavages, by cyclic processes involving adjacent substituents, or by bicyclic processes of adjacent substituents.Evidence for a form of +. in which charge and radical site are separate is assembled from the spectra.

Influence of Boiling on the Radiolysis of Diglyme


, p. 312 - 318 (2018/08/01)

The radiolysis of diethylene glycol dimethyl ether (diglyme) in a boiling state has been studied for the first time. Boiling facilitates the cleavage of internal C–O bonds, weakens the cage effect and diglyme regeneration processes, and facilitates the exchange and dimerization reactions of radicals. As compared with radiolysis at room temperature, the amount of unsaturated products of diglyme fragmentation formed during irradiation in the boiling state is smaller by a factor of 4, and the disproportionation products of heavy radicals are found in negligible amounts, if any. The yield of radiolytic decomposition of diglyme under boiling conditions is ~15 molecule/100 eV, which is higher than that at room temperature by a factor of almost 1.5.

Mild partial deoxygenation of esters catalyzed by an oxazolinylborate-coordinated rhodium silylene

Xu, Songchen,Boschen, Jeffery S.,Biswas, Abhranil,Kobayashi, Takeshi,Pruski, Marek,Windus, Theresa L.,Sadow, Aaron D.

, p. 15897 - 15904 (2015/09/15)

An electrophilic, coordinatively unsaturated rhodium complex supported by borate-linked oxazoline, oxazoline-coordinated silylene, and N-heterocyclic carbene donors [{κ3-N,Si,C-PhB(OxMe2)(OxMe2SiHPh)ImMes}Rh(H)CO][HB(C6F5)3] (2, OxMe2 = 4,4-dimethyl-2-oxazoline; ImMes = 1-mesitylimidazole) is synthesized from the neutral rhodium silyl {PhB(OxMe2)2ImMes}RhH(SiH2Ph)CO (1) and B(C6F5)3. The unusual oxazoline-coordinated silylene structure in 2 is proposed to form by rearrangement of an unobserved isomeric cationic rhodium silylene species [{PhB(OxMe2)2ImMes}RhH(SiHPh)CO][HB(C6F5)3] generated by H abstraction. Complex 2 catalyzes reductions of organic carbonyl compounds with silanes to give hydrosilylation products or deoxygenation products. The pathway to these reactions is primarily influenced by the degree of substitution of the organosilane. Reactions with primary silanes give deoxygenation of esters to ethers, amides to amines, and ketones and aldehydes to hydrocarbons, whereas tertiary silanes react to give 1,2-hydrosilylation of the carbonyl functionality. In contrast, the strong Lewis acid B(C6F5)3 catalyzes the complete deoxygenation of carbonyl compounds to hydrocarbons with PhSiH3 as the reducing agent.

A novel sol-gel approach to highly condensed silicas at low temperature

Jorapur, Yogesh R.,Mizoshita, Norihiro,Maegawa, Yoshifumi,Nakagawa, Hiroki,Hasegawa, Takeru,Tani, Takao,Inagaki, Shinji,Shimada, Toyoshi

supporting information; scheme or table, p. 280 - 281 (2012/05/31)

We have discovered new Meerwein's reagent-catalyzed solgel polycondensations, which provide highly condensed silica Q4 and biphenylylene silica T3 as amorphous gels with marginal silanols starting from TEOS and 4,4′-bis(triethoxysilyl)biphenyl (BTEBph), respectively. We propose a plausible pathway for this protocol with possible silyloxonium intermediates.

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