10298-81-4Relevant academic research and scientific papers
High-speed microwave assisted synthesis of SEA0400 - A selective inhibitor of the Na+/Ca2+ exchanger
De La Cruz, Gemma Guedes,Groschner, Klaus,Oliver Kappe,Glasnov, Toma N.
supporting information; experimental part, p. 3731 - 3734 (2012/09/22)
An efficient and rapid five-step synthesis of SEA0400, a selective Na +/Ca2+ exchanger (NCX) inhibitor, using controlled microwave heating is reported. In addition, a novel three-step route omitting the key Baeyer-Villiger oxidation/
NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE
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Page/Page column 67, (2010/12/29)
The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect and feeding suppressant effect. The present invention provides a compound represented by the general formula (I), or pharmacologically acceptable salt thereof: [wherein, R1 represents a phenylaminocarbonyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, a benzoxazol-2-yl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group A, or the like; R2 independently represents a C1-C6 alkyl group; R3 represents a group represented by the formula -C(=O)-O-R4 or the like; R4 represents a hydrogen atom, a C1-C6 alkyl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group B, or the like; X represents an oxygen atom, a methylene group, or a group represented by the formula -NH-, or the like; L represents a single bond, a methylene group, or the like;...... represents a single bond or a double bond; m represents 1 or 2; n represents an integer of 0 to 5; Substituent Group A represents a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a C1-C6 alkoxy group, or the like; and Substituent Group B represents a C3-C6 cycloalkyl group, a phenyl group, a carboxyl group, or the like].
