102996-95-2

Upstream product

• 188290-36-0 thiophene 
• 3634-89-7 N-(p-toluenesulfonyl)aziridine 
• 30433-91-1 [2-(2-thyenyl)ethyl]amine 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 102996-96-3 ethyl N,N-<2-(2-thienyl)ethyl>tosylglycinate 
• 102997-16-0 6-(2-chlorobenzyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-d>azepine 
• 102997-01-3 5,6,7,8-tetrahydro-4H-thieno<2,3-d>azepine 
• 102996-97-4 N,N-<2-(2-thienyl)ethyl>tosylglycine 
• 102996-99-6 4-hydroxy-6-tosyl-5,6,7,8-tetrahydro-4H-thieno<2,3-d>azepine 
• 102996-98-5 6-tosyl-5,6,7,8-tetrahydrothieno<2,3-d>azepin-4-one 
• 102997-02-4 6-tosyl-7,8-dihydro-6H-thieno<2,3-d>azepine 
• 30433-91-1 [2-(2-thyenyl)ethyl]amine 

Relevant academic research and scientific papers

Direct Synthesis of α-Amino Nitriles from Sulfonamides via Base-Mediated C-H Cyanation

Herein, we disclose a transition-metal-free reaction system that enables α-cyanation of sulfonamides through C-H bond cleavage for the preparation of α-amino nitriles, including difficult-to-access all-alkyl α-tertiary scaffolds. More than 50 substrate examples prove a wide functional group tolerance. Additionally, its synthetic practicality is highlighted by gram-scalability and the late-stage modification of natural compounds. Mechanistic experiments suggest that this process involves in situ formation of an imine intermediate via base-promoted elimination of HF.

NaI-Catalyzed Oxidative Amination of Aromatic Sodium Sulfinates: Synergetic Effect of Ethylene Dibromide and Air as Oxidants

A novel NaI-catalyzed oxidative amination of sodium sulfinates, employing both ethylene dibromide (EDB) and air as the oxidants, is described. EDB was first demonstrated to be a promising mild organic oxidant that in air, converted NaI into molecular iodine to promote the cross-coupling reactions of aromatic sodium sulfinates with amines to produce arylsulfonamides. Mechanistic studies indicated that a radical pathway might be involved in the reaction process.

Enantioselective Synthesis of trans-Vicinal Diamines via Rhodium-Catalyzed [2+2] Cycloaddition of Allenamides

An efficient protocol for the enantioselective Rh-catalyzed intermolecular head-to-head [2+2] cycloaddition of allenamides was developed. A variety of enantio-enriched cyclobutane-1,2-diamine derivatives were achieved in good yields with good to excellent enantioselectivities. (Figure presented.).

Synthese von 2-(2-Aminoethyl)thiophen ueber aktivierte Arylsulfonylaziridine

Synthesis of 2-(2-Aminoethyl)thiophene via Activated Arylsulfonylaziridines.Activated arylsulfonylaziridines react with 2-lithiothiophene under ring cleavage to afford sulfonamides 2, reductive cleavage of which with sodium bis(2-methoxyethoxy)aluminiumhydride yields 2-(2-aminoethyl)thiophene (3).