103-00-4

Basic information

• Product Name: 2-Propanol, 1-(cyclohexylamino)-
• Synonyms: 1-cyclohexylaminopropan-2-ol
• CAS NO: 103-00-4
• Molecular Formula: C₉H₁₉NO
• Molecular Weight: 157.25326
• EINECS: 203-069-7
• Mol File: 103-00-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 45.6°C
• Boiling Point: 281.94°C (rough estimate)
• Flash Point: 107.1°C
• Appearance: /
• Density: 0.9526 (rough estimate)
• Vapor Pressure: 0.000641mmHg at 25°C
• Refractive Index: 1.4248 (estimate)
• CAS DataBase Reference: 2-Propanol, 1-(cyclohexylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 1-(cyclohexylamino)-(103-00-4)
• EPA Substance Registry System: 2-Propanol, 1-(cyclohexylamino)-(103-00-4)

Safety Data

• Hazardous Substances Data: 103-00-4(Hazardous Substances Data)

Usage

General Description

1-(Cyclohexylamino)-2-propanol is a chemical compound with a molecular structure that features a cyclohexylamino group (C6H11NH2) attached to a propanol (C3H7OH) molecule. Its versatile chemical structure makes it valuable in the field of organic chemistry.

Uses

1-(Cyclohexylamino)-2-propanol is an intermediate in the synthesis of Hexylcaine Hydrochloride which is used in pain management in as an antifungal agent. Anaesthetic.

InChI:InChI=1/C9H19NO/c1-8(11)7-10-9-5-3-2-4-6-9/h8-11H,2-7H2,1H3

Upstream product

• 108-94-1 cyclohexanone 
• 78-96-6 3-amino-2-propanol 
• 108-91-8 cyclohexylamine 
• 75-56-9 methyloxirane 
• 90267-83-7 2-methyl-1-oxa-4-aza-spiro[4.5]decane 
• 124-38-9 carbon dioxide 
• 1833-53-0 2-(Trimethylsilyloxy)propene 
• 108-32-7 1,2-propylene cyclic carbonate 
• 5445-92-1 (2-chloro-propyl)-cyclohexyl-amine; hydrochloride 

Downstream Products

• 1431326-46-3 tert-butyl cyclohexyl(2-hydroxypropyl)carbamate 
• 1431325-96-0 N-[2-((4-isopropylbenzoyl)oxy)propyl]-N,N-dimethylcyclohexanaminium iodide 
• 1431326-51-0 1-(cyclohexyl(methyl)amino)propan-2-yl-4-isopropylbenzoate 
• 1431325-89-1 N-[2-((2-isopropylbenzoyl)oxy)propyl]-N,N-dimethylcyclohexanaminium iodide 
• 1431326-49-6 1-(cyclohexyl(methyl)amino)propan-2-yl2-isopropylbenzoate 
• 1423166-01-1 1-(2-cyclohexyl-1,1-dioxo-isothiazolidin-3-yl)-ethanone 
• 1423165-93-8 2-cyclohexyl-4-methyl-5-methylene-1,1-dioxo-isothiazolidin-4-ol 
• 1423165-77-8 5-cyclohexyl-7-methyl-[1,4,5]-oxathiazepane-4,4-dioxide 
• 1423165-85-8 C₁₁H₁₉NO₃S 
• 1423165-69-8 C₁₁H₂₁NO₃S 
• 1423165-61-0 C₁₇H₃₅NO₃SSi 
• 78345-60-5 1-(cyclohexyl(methyl)amino)propan-2-ol 
• 532-76-3 hexylcaine hydrochloride 
• 119014-06-1 diphenic acid ethyl ester-(β-cyclohexylamino-isopropyl ester); hydrochloride 

Relevant articles and documents

One-Pot Synthesis of Disubstituted Urea from Carbon Dioxide, Propylene Oxide, and Amines Catalyzed by Imidazolium-Tetraiodoindate

In this article, synthesis of 1,3-disubstituted urea (DSU) from three component reagent systems comprising amine, carbon dioxide, and propylene oxide is described. DSU is synthesized in the presence of a variety of ionic liquids (ILs) with/without promoters. Among used ILs, 1-butyl-3-methylimidazolium tetraiodoindateIII (represented as [Bmim][InI4]) is found to give the highest DSU product. A serious experiment clearly indicates that the tetraiodoindate anion plays an important role for the selective production of the DSU. Based on the in situ infrared spectroscopic studies, a plausible reaction mechanism for producing dicyclohexylurea from cyclohexylamine is proposed. The synthesis and characterization of [Bmim][InI4] are given in details. Moreover, the effect of reaction variables such as time, temperature, pressure, and the molar ratio of substrate to catalyst is also studied.

Process for Preparing Disubstituted Urea and Carbamate Compounds from Amines, Carbon Dioxide, and Epoxides

The present disclosure relates to a method for preparing a disubstituted urea and carbamate compounds simultaneously through a one-pot reaction of an amine, carbon dioxide and an alkylene oxide compound in the presence of an ionic liquid-based complex catalyst system containing indium. In accordance with the present disclosure, a disubstituted urea and carbamate compounds can be prepared simultaneously at high yield. In addition, the ionic liquid-based catalyst containing indium according to the present disclosure is economical because it can be reused several times.

Syntheses of five- and seven-membered ring sultam derivatives by Michael addition and Baylis-Hillman reactions

Five- and seven-membered sultam derivatives were conveniently synthesized via intra- or intermolecular Michael additions and an improved vinyl sulfonamide Baylis-Hillman reaction. Two different cyclization pathways were explored for the oxa-Michael reaction. A good solvent was discovered for an otherwise sluggish ketone-type Baylis-Hillman reaction in which vinyl sulfonamide ketones were used as the precursors. Furthermore, a strong base caused vinyl sulfonamide ketones to undergo 5-endo-trig intramolecular cyclizations, which are disfavored according to Baldwin's rule. Finally Baylis-Hillman reaction products were used as scaffolds for diversity-oriented sultam syntheses.