1030612-07-7Relevant academic research and scientific papers
Biomimetic synthesis of antrodia maleimides and maleic anhydrides
Boukouvalas, John,Albert, Vincent
, p. 939 - 944 (2014/01/17)
A simple and efficient biomimetic synthesis of Antrodia maleimides and maleic anhydrides, including the HCV protease inhibitor antrodin A, is described. The key step is a Perkin-type condensation performed under exceptionally mild conditions.
Unified route to asymmetrically substituted butenolide, maleic anhydride, and maleimide constituents of Antrodia camphorata
Boukouvalas, John,Albert, Vincent,Loach, Richard P.,Lafleur-Lambert, Raphael
, p. 9592 - 9597,6 (2020/08/20)
The first synthesis of antrocinnamomin D and a new synthesis of antrodins A and B have been achieved in 6-8 steps and high overall efficiency (51, 46, and 43%, respectively) from commercially available methyl 4-hydroxyphenylacetate. Key steps include Fuerstner-Kochi iron-catalyzed sp2-sp 3 cross-coupling and 2-silyloxyfuran oxyfunctionalization.
