656830-24-9Relevant academic research and scientific papers
Biomimetic synthesis of antrodia maleimides and maleic anhydrides
Boukouvalas, John,Albert, Vincent
, p. 939 - 944 (2014/01/17)
A simple and efficient biomimetic synthesis of Antrodia maleimides and maleic anhydrides, including the HCV protease inhibitor antrodin A, is described. The key step is a Perkin-type condensation performed under exceptionally mild conditions.
Unified route to asymmetrically substituted butenolide, maleic anhydride, and maleimide constituents of Antrodia camphorata
Boukouvalas, John,Albert, Vincent,Loach, Richard P.,Lafleur-Lambert, Raphael
, p. 9592 - 9597,6 (2020/08/20)
The first synthesis of antrocinnamomin D and a new synthesis of antrodins A and B have been achieved in 6-8 steps and high overall efficiency (51, 46, and 43%, respectively) from commercially available methyl 4-hydroxyphenylacetate. Key steps include Fuerstner-Kochi iron-catalyzed sp2-sp 3 cross-coupling and 2-silyloxyfuran oxyfunctionalization.
Total synthesis of (±)-camphorataimides and (±)-himanimides by NaBH4/Ni(OAc)2 or Zn/AcOH stereoselective reduction
Cheng, Chia-Fu,Lai, Zhen-Chang,Lee, Yean-Jang
, p. 4347 - 4353 (2008/09/20)
Maleic anhydride 1 of Antrodia camphorate, which can be isolated from Chinese herbal medicine, is achieved in which the longest linear sequence is only five steps, in 40% overall yield from commercially available succinic anhydride. The crucial antrodimid
A concise synthesis of maleic anhydride and maleimide natural products found in Antrodia camphorata
Stewart, Scott G.,Polomska, Marta E.,Lim, Rou Wei
, p. 2241 - 2244 (2007/10/03)
Recently, the natural products maleic anhydride 1 and maleimides 2 and 3 have been isolated from the mycelium of Antrodia Camphorata, each displaying activity in LLC cell lines. We describe a concise synthesis of each of these natural compounds utilizing C-C cross-coupling methodology, namely, the Negishi and Suzuki reactions. This efficient and high yielding synthesis is convergent lending itself to production of medicinal analogues.
Synthesis of natural cytotoxic camphorataimides B and C
Baag, Merajuddin,Argade, Narshinha P.
, p. 1005 - 1008 (2007/10/03)
Recently isolated camphorataanhydride A and cytotoxic camphorataimides B and C have been synthesized using chemoselective SN2′ Grignard coupling reaction of p-methoxyphenyl-magnesium bromide with dimethyl bromomethylfumarate and chemoselective
Novel mixture and compounds from mycelia of Antrodia camphorata and use thereof
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, (2008/06/13)
The present invention relates to novel mixture and maleic and succinic acid derivatives from mycelium of Antrodia Camphorata and the medical use thereof. The present invention relates to the composition or mycelium comprising the compounds of the invention.
