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(1R,4S)-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one, commonly known as (R)-Benzyl Tropane, is a chiral compound with a bicyclic structure. It is a key intermediate in the synthesis of certain pharmaceuticals and psychoactive substances. Tropane alkaloids, such as cocaine and atropine, are chemically related to (1R,4S)-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one and share its bicyclo[2.2.1]heptane ring system. (R)-Benzyl Tropane exhibits a high binding affinity for dopamine transporters and is therefore implicated in drug addiction and abuse. It is also used as a chemical building block in the synthesis of various drugs with potential therapeutic applications.

103065-89-0

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103065-89-0 Usage

Uses

Used in Pharmaceutical Industry:
(1R,4S)-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one is used as a key intermediate in the synthesis of certain pharmaceuticals for its high binding affinity for dopamine transporters. This property makes it a valuable component in the development of drugs targeting dopamine-related disorders and conditions.
Used in Psychoactive Substances:
(1R,4S)-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one is used as a chemical building block in the synthesis of psychoactive substances due to its structural similarity to tropane alkaloids like cocaine and atropine. Its involvement in drug addiction and abuse research highlights its importance in understanding and potentially treating substance use disorders.
Used in Drug Addiction and Abuse Research:
(1R,4S)-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one is used as a research compound to study the mechanisms of drug addiction and abuse. Its high binding affinity for dopamine transporters makes it a crucial tool for investigating the neurological and behavioral aspects of substance abuse and for developing potential therapeutic interventions.

Check Digit Verification of cas no

The CAS Registry Mumber 103065-89-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,0,6 and 5 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 103065-89:
(8*1)+(7*0)+(6*3)+(5*0)+(4*6)+(3*5)+(2*8)+(1*9)=90
90 % 10 = 0
So 103065-89-0 is a valid CAS Registry Number.

103065-89-0Relevant academic research and scientific papers

Synthesis of monohydroxylated 2-azabicyclo[2.2.1]heptan-3-ones

Palmer, Christopher F.,Webb, Ben,Broad, Susan,Casson, Sharon,McCague, Raymond,Willetts, Andrew J.,Roberts, Stanley M.

, p. 1299 - 1302 (2007/10/03)

Oxymercuration/demercuration of 2-benzyl-2-azabicyclo[2.2.1]hept-5-en-3-one (1) and biohydroxylation of the corresponding saturated lactam (-)-(8) are compared as methods for the preparation of monohydroxylated 2-azabicyclo[2.2.1]heptan-3-ones.

BIOHYDROXYLATION D'UN AZA-2 BICYCLO HEPTANE

Archelas, Alain,Morin, Christophe

, p. 1277 - 1278 (2007/10/02)

Biohydroxylation with Beauveria sulfurescens of the 5-exo position of the 2-aza bicycloheptane ring system gives rise to a precursor of carbocyclic 2'-deoxy nucleosides.

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