262279-96-9Relevant academic research and scientific papers
A new class of conformationally rigid analogues of 4-amino-5- halopentanoic acids, potent inactivators of γ-aminobutyric acid aminotransferase
Qiu, Jian,Silverman, Richard B.
, p. 706 - 720 (2007/10/03)
Recently, we found (Qiu, J.; Pingsterhaus, J. M.; Silverman, R. B. J. Med. Chem. 1999, 42, 4725-4728) that conformationally rigid analogues of the GABA aminotransferase (GABA-AT) inactivator vigabatrin were not inactivators of GABA-AT. To determine if thi
Rearrangement of 2-Azabicyclohept-5-en-3-ones: Synthesis of cis-3-Aminocyclopentane Carboxylic Acid Derivatives
Palmer, Christopher F.,Parry, Keith P.,Roberts, Stanley M.,Sik, Vladimir
, p. 1021 - 1028 (2007/10/02)
The γ-lactam 4 was converted into the bromo ester 6 and the latter compound was transformed in five steps into the diester 10.Similarly the lactam 4 was converted into the hydroxy amide 17 via the intermediacy of the dihalogeno compound 11.Compounds 10 an
