1031432-91-3Relevant academic research and scientific papers
Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents
Basarab, Gregory S.,Manchester, John I.,Bist, Shanta,Boriack-Sjodin, P. Ann,Dangel, Brian,Illingworth, Ruth,Sherer, Brian A.,Sriram, Shubha,Uria-Nickelsen, Maria,Eakin, Ann E.
, p. 8712 - 8735 (2013/12/04)
The discovery and optimization of a new class of bacterial topoisomerase (DNA gyrase and topoisomerase IV) inhibitors binding in the ATP domain are described. A fragment molecule, 1-ethyl-3-(2-pyridyl)urea, provided sufficiently potent enzyme inhibition (
HETEROCYCLIC UREA DERIVATIVES USEFUL FOR TREATMENT OF BACTERIAL INFECTION
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Page/Page column 234-235, (2011/04/14)
Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF
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Page/Page column 111-112, (2010/12/26)
Compounds of formula (IA) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF
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Page/Page column 47-48, (2010/12/29)
Compounds of formula (IA) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
HETEROCYCLIC UREA DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS
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Page/Page column 272, (2009/12/28)
Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
CHEMICAL COMPOUNDS
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Page/Page column 69, (2008/12/05)
Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also desc
