103144-79-2Relevant academic research and scientific papers
CATALYTIC ASYMMETRIC SYNTHESIS OF PEPTIDES ON POLYMER SUPPORT
Ojima, Iwao,Tsai, Chung-Ying,Zhang, Zhaoda
, p. 5785 - 5788 (1994)
A novel approach to the synthesis of peptides through the catalytic asymmetric hydrogenation of dehydrotripeptides linked to the Wang resin, using rhodium complexes with chiral diphosphine ligands as the catalysts, is described
THAL, a sterically unhindered linker for the solid-phase synthesis of acid-sensitive protected peptide acids
Isidro-Llobet, Albert,Boas, Ulrik,Jensen, Knud J.,Alvarez, Mercedes,Albericio, Fernando
experimental part, p. 7342 - 7344 (2009/04/18)
(Chemical Equation Presented) The 5-(4-hydroxyphenyl)-3,4- ethylenedioxythienyl alcohol (THAL, Thiophene Acid Labile) is described as a new linker for the solid-phase synthesis of peptide carboxylic acids. It is based on the electron-rich 3,4-ethylenedioxythenyl (EDOTn) moiety and allows the obtention of free and tert-butyl-protected peptides by cleavage with 90% and 0.5% TFA, respectively. This very high acid lability makes it useful for the synthesis of sensitive peptides. Free and tert-butyl- protected Leu-enkephalins have been synthesized as models to demonstrate the utility of the linker.
Synthesis of peptide derivatives of 5-fluorouracil
Nichifor, Marieta,Schacht, Etienne H.
, p. 3747 - 3760 (2007/10/02)
The preparation of di-, tetra- and pentapeptides carrying 5-fluorouracil as an α-substituent of a terminal glycine moiety is described. The dipeptide compounds were synthetized by addition of ethyl glyoxylate to N-(benzyl-oxycarbonyl)-amino acid amides, s
