15373-56-5

Upstream product

• 3303-55-7 L-Phe-Leu 
• 81917-66-0 N-(1-Benzotriazolylcarbonyl)-glycin 
• 88767-09-3 N-(c-NOPY)-glycyl-L-phenylalanyl-L-leucine 
• 76939-20-3 Z(OMe)-Gly-Phe-Leu-OH 
• 81917-69-3 N-(1-Benzotriazolylcarbonyl)-L-phenylalanin 
• 4530-20-5 BOC-glycine 
• 61-90-5 L-leucine 
• 63808-83-3 Z(OMe)-Phe-Leu-OH 

Downstream Products

• 126530-22-1 Ac-Tyr-Gly-Phe-Leu 
• 103144-79-2 Fmoc-Gly-Phe-Leu-OH 
• 913640-35-4 C₂₃H₄₁N₃O₄Si₂ 
• 913640-38-7 Fmoc-Tyr(t-Bu)-Gly-ψ(NH-CO-NH)-Gly-Phe-Leu-OH 
• 112037-32-8 H-Tyr-Gly-Φ(NHCONH)-Gly-Phe-Leu-OH 
• 76939-25-8 H-Tyr-Arg-Gly-Phe-Leu-OH 
• 2541-27-7 N-benzyloxycarbonyl-(S)-tyrosinyl-glycine 
• 80645-37-0 (S)-2-[(S)-2-(2-{2-[(S)-2-Benzyloxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 

Relevant academic research and scientific papers

Substituted 3-pyrroline-2-one amino blocking reagents and intermediates therefor

An amino blocking reagent, 1-isopropyl-3-ethoxy-4-nitro-2-oxo-3-pyrroline has been obtained. The new reagent is water soluble. It has yielded an N-protected glycine active ester with solubiity appropriate for reaction with both peptides and proteins. N-hydroxysuccinimide esters of N-i-NOPY- and N-c-NOPY-glycines were prepared. The N-hydroxysuccinimide active esters were produced by treatment with dicyclohexylcarbodimide (DCC) and N-hydroxysuccinimide in tetrahydrofuran (THF). The new reagents for glycine attachment are stable crystalline compounds. These active esters were used to attach glycine residues to a dipeptide and a protein by the salt-coupling procedure.

Application of 4-Polystyryltriphenylmethyl Chloride to the Syntheses of Peptides and Amino Acid Derivatives

Use of polymer-bound trityl chloride as an α-amino protecting group of amino acids allows simple and high-yield syntheses of amino acid derivatives and peptides.

Tripeptides and their use

Tripeptides composed of the amino acids glycine, leucine, and phenylalanine or tyrosine obtainable by fractionation of hydrolysis products of human casein or by direct synthesis can be used as immunostimulants.

" Mediator Methodology" for the Synthesis of Peptides in a Two-Polymeric System

Abstract: A novel methodology is described for a potential automated self-controlled synthesis of peptides.The method is based on transferring an N-protected amino acid from one insoluble polymer (donor) such as a polymeric o-nitrophenyl ester (a "bank" of active ester) to an insoluble polymer-bound amino acid (acceptor),with the aid of a soluble mediator molecule (shadchan)2 The method gives high yields of pure peptides by garanteeing stoichiomeric supply of the active ester and allowing self monitoring.When the polymer-bound (dimethylamino)pyridinium salts, the condensation reaction was expended to also include sulfonation and particularly phosphorylation reactions.