103150-78-3

Upstream product

• 123-32-0 2,5-dimethyl-pyrazine 
• 23046-95-9 2,3,5-pyrazine-tricarboxylic acid 
• 7732-18-5 water 
• 64-19-7 acetic acid 
• 122-05-4 2,5-pyrazinedicarboxylic acid 
• 64-17-5 ethanol 
• 1906-82-7 ethyl acetamidoacetate 
• 109-94-4 formic acid ethyl ester 
• 43193-60-8 pyrazine-2,3,5,6-tetracarboxylic acid 
• 68538-87-4 1,1'-pyrazine-2,5-diyl-bis-butane-1,2,3,4-tetraol 
• 7722-84-1 dihydrogen peroxide 

Downstream Products

• 31722-48-2 2,5-dicyanopyrazine 
• 891782-63-1 5-((tert-butoxycarbonyl)amino)pyrazine-2-carboxylic acid 
• 177759-80-7 ethyl 5-(tert-butoxycarbonylamino)pyrazine-2-carboxylate 
• 1124214-45-4 N-tert-butyl-3-((4-(5-(3-phenylureido)pyrazine-2-carbonyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate 
• 1124214-52-3 tert-butyl 5-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)pyrazin-2-ylcarbamate 
• 1124214-54-5 3-((4-(2-aminopyrazine-5-carbonyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide 
• 290-37-9 1,4-pyrazine 
• 98-97-5 2-pyrazylcarboxylic acid 

Relevant academic research and scientific papers

Reductive Silylation Using a Bis-silylated Diaza-2,5-cyclohexadiene

1,4-Bis(trimethylsilyl)-1,4-diaza-2,5-cyclohexadiene, 1, was tested as a reagent for the reductive silylation of various unsaturated functionalities, including N-heterocycles, quinones, and other redox-active moieties in addition to deoxygenation of main group oxides. Whereas most reactions tested are thermodynamically favorable, based on DFT calculations, a few do not occur, perhaps giving limited insight on the mechanism of this very attractive reductive process. Of note, reductive silylation reactions show a strong solvent dependence where a polar solvent facilitates conversions.

Synthesis of substituted esters of imidazoles, oxazoles, thiazoles, and diethyl pyrazine-2,5-dicarboxylate from a common acyclic precursor employing C-formylation strategy

A novel synthetic route to substituted esters of imidazoles, oxazoles, thiazoles, and diethyl pyrazine-2,5-dicarboxylates via C-formylation of glycine ethyl ester hydrochloride is reported. This methodology is simple, robust, and gives good yields of different heterocyclic esters in one or two steps from a common acyclic precursor and is amenable to large scale synthesis.

N-BENZYL,N'-ARYLCARBONYLPIPERAZINE DERIVATIVES

The present invention relates to N-benzyl,N′-arylcarbonylpiperazine derivatives having the general formula I to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N′-arylcarbonylpiperazine derivatives for the manufacture o

N-BENZYL, N'-ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS

The present invention relates to N-benzyl,N'-arylcarbonylpiperazine derivatives having the general Formula (I) to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N'-arylcarbonylpiperazine derivatives for the manufacture