diethyl pyrazine-2,5-dicarboxylate

Base Information

• Chemical Name: diethyl pyrazine-2,5-dicarboxylate
• CAS No.: 103150-78-3
• Molecular Formula: C10H12N2O4
• Molecular Weight: 224.216
• Mol file: 103150-78-3.mol

Synonyms:diethyl pyrazine-2,5-dicarboxylate;2,5-Pyrazinedicarboxylic acid, diethyl ester

Chemical Property of diethyl pyrazine-2,5-dicarboxylate

Chemical Property:

• PSA: 78.38000
• LogP: 0.83000

Purity/Quality:

97% ^*data from raw suppliers

Diethyl pyrazine-2,5-dicarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl pyrazine-2,5-dicarboxylate

There total 11 articles about diethyl pyrazine-2,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethyl acetamidoacetate (1906-82-7) + formic acid ethyl ester (109-94-4) → diethyl pyrazine-2,5-dicarboxylate (103150-78-3)

Guidance literature:

ethyl acetamidoacetate; formic acid ethyl ester; With 18-crown-6 ether; sodium hydride; In toluene; at 20 - 60 ℃; for 1h; Cooling with ice;

With hydrogenchloride; In ethanol; water; toluene; at 65 ℃; for 2h; pH=4;

DOI:10.1016/j.tetlet.2014.03.039

Reference yield:

2,5-dimethyl-pyrazine (123-32-0) → 2-methylpyrazin-5-carboxylic acid (5521-55-1) + diethyl pyrazine-2,5-dicarboxylate (103150-78-3)

Guidance literature:

With potassium permanganate;

Reference yield:

2,3,5-pyrazine-tricarboxylic acid (23046-95-9) → pyrazine-2,6-dicarboxylic acid (940-07-8) + diethyl pyrazine-2,5-dicarboxylate (103150-78-3)

Guidance literature:

With water;

upstream raw materials:

2,5-dimethyl-pyrazine

2,3,5-pyrazine-tricarboxylic acid

dihydrogen peroxide

1,1'-pyrazine-2,5-diyl-bis-butane-1,2,3,4-tetraol

Downstream raw materials:

1,4-pyrazine

2-pyrazylcarboxylic acid

3-((4-(2-aminopyrazine-5-carbonyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

tert-butyl 5-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)pyrazin-2-ylcarbamate