1031685-23-0

Basic information

• Product Name: 2-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]methyl acetate
• Synonyms: 2-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]methyl acetate
• CAS NO: 1031685-23-0
• Molecular Weight: 343.403
• Mol File: 1031685-23-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]methyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]methyl acetate(1031685-23-0)
• EPA Substance Registry System: 2-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]methyl acetate(1031685-23-0)

Safety Data

• Hazardous Substances Data: 1031685-23-0(Hazardous Substances Data)

Upstream product

• 87-51-4 indole-3-acetic acid 
• 1912-33-0 Indole-3-acetic acid methyl ester 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 128742-77-8 [N-(p-toluenesulfonyl)indol-3-yl]acetic acid 
• 1031685-31-0 C₂₆H₃₁N₃O₄S 

Relevant articles and documents

Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors

The multiple roles of protein kinase D (PKD) in various cancer hallmarks have been repeatedly reported. Therefore, the search for novel PKD inhibitors and their evaluation as antitumor agents has gained considerable attention. In this work, novel pyrazolo[3,4-d]pyrimidine based pan-PKD inhibitors with structural variety at position 1 were synthesized and evaluated for biological activity. Starting from 3-IN-PP1, a known PKD inhibitor with IC50 values in the range of 94–108 nM, compound 17m was identified with an improved biochemical inhibitory activity against PKD (IC50 = 17–35 nM). Subsequent cellular assays demonstrated that 3-IN-PP1 and 17m inhibited PKD-dependent cortactin phosphorylation. Furthermore, 3-IN-PP1 displayed potent anti-proliferative activity against PANC-1 cells. Finally, a screening against different cancer cell lines demonstrated that 3-IN-PP1 is a potent and versatile antitumoral agent.

Synthesis and biological evaluation of benzothiazole incorporated 1-phenylsulfonylindole-3-acetamide derivatives

Indole-3-acetic acid was esterified to give methyl ester (2), which was treated with substituted aromatic sulphonyl chloride in alkaline media to give 2-[1-(phenyl sufonyl-1H-indole-3-yl]methyl acetate (3). Further the compound 3 was converted to acid (4). Finally compound 4 was coupled with 6-substituted benzothiazole-2-amines by means of EDC to give acetamide derivatives (5a-i). The structures of the newly synthesized compounds have been established by analytical and spectral methods. These compounds have also been screened for analgesic activity.