103185-50-8

Upstream product

• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 
• 93-91-4 1-phenylbutan-1,3-dione 
• 121-69-7 N,N-dimethyl-aniline 
• 98-94-2 N,N-dimethyl-cyclohexanamine 
• 1634-04-4 tert-butyl methyl ether 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 103-83-3 N,N'-dimethylbenzylamine 
• 1704-14-9 4-hydroxy-4-phenylbut-3-en-2-one 

Downstream Products

• 84198-58-3 5,5'-diphenyl-3,3'-dimethyl-4,4'-methylendiisoxazole 

Relevant academic research and scientific papers

Selectfluor facilitated bridging of indoles to bis(indolyl)methanes using methyl: Tert -butyl ether as a new methylene precursor

A novel, green and efficient method is developed for the synthesis of methylene bridged bis(indolyl)methanes in good to excellent yields. The reaction employs methyl tert-butyl ether (MTBE) as the methylene source and selectfluor as an oxidizing agent. The scope and versatility of the methods have been successfully demonstrated with 48 examples. The metal-free transformation process is suitable for scale-up production. A selectfluor-promoted oxidative reaction mechanism is proposed based on the results of the experimental studies. This journal is

Rose Bengal-photosensitized oxidation of tertiary amines for the synthesis of bis-1,3-dicarbonyl compounds

We report an example of Rose Bengal-photosensitized oxidation of tertiary amines for the synthesis of bis-1,3-dicarbonyl compounds. This protocol employs Rose Bengal as a visible-light absorbing photocatalyst without the need of a transition metal, and air as a green oxidant. Various functional groups were well tolerated to afford products with yields of up to 80% under mild reaction conditions.

Oxidative C(Sp3)-H activation and C-N cleavage of N-methyl amines under transition-metal-free condition for synthesis of methylene-bridged bis-1,3-diketones

A transition-metal-free oxidative methylenation reaction was developed. Methylene-bridged bis-1,3-dicarbonyl compounds were synthesized by oxidative C(Sp3)-H activation and C-N cleavage of N-methyl amines. This novel reaction avoids the use of

Functionalization of aliphatic tertiary amines mediated by hexachloroethane/cat. Copper: Synthesis of propargylic amines and methylene-bridged bis-1,3-dicarbonyl derivatives

Copper-catalyzed functionalization of aliphatic tertiary amines with the assistance of C2Cl6 is described. This method details the alkynylation of aliphatic tertiary amines and the synthesis of methylene-bridged bis-1,3-dicarbonyl de

Aerobic oxidation of a tertiary aliphatic amine under visible-light photocatalysis: Facile synthesis of methylene-bridged bis-1,3-dicarbonyl compounds

Lights, camera, action! An efficient protocol for the formation of methylene-bridged bis-1,3-dicarbonyl compounds has been developed through an aerobic photocatalytic oxidative coupling reaction between 1,3-dicarbonyl compounds and a tertiary aliphatic amine. Copyright

Gold/copper-catalyzed activation of the aci-form of nitromethane in the synthesis of methylene-bridged bis-1,3-dicarbonyl compounds

Activation of the aci-form of nitromethane using Lewis acids for the attack of carbon nucleophiles was studied. 1,3-Dicarbonyl compounds in the presence of catalytic amounts of AuCl3 or Cu(OTf)2 in nitromethane solvent could be converted into methylene-bridged bis-1,3-dicarbonyl compounds.

Iron-catalyzed selective oxidation of N-methyl amines: highly efficient synthesis of methylene-bridged bis-1,3-dicarbonyl compounds

Methylene-bridged bis-1,3-dicarbonyl derivatives were synthesized efficiently by Iron-catalyzed oxidative reactions of 1,3-dicarbonyl compounds and N,N-dimethylaniline. Blpyrazoles and substituted 1,4-dlhydropyridlne were obtained by the reactions of bis-1,3-dicarbonyl compounds with hydrazines and ammonium acetate, respectively.

13C and 1H NMR SPECTRA AND STRUCTURE OF THE PRODUCTS FROM THE CONDENSATION OF 1,3-DICARBONYL COMPOUNDS WITH ALDEHYDES

The structure of the diadducts formed in the reaction of 1,3-dicarbonyl compounds with aldehydes in a ratio of 2:1 under the conditions of the Knoevenagel condensation was studied by 13C and 1H NMR spectroscopy.It was shown that acyclic tetracarbonyl comp