103185-89-3Relevant academic research and scientific papers
Aromatic hydroxamic acid compounds, their production and use
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, (2008/06/13)
The present invention relates to a compound of the formula: STR1 wherein Ar represents an optionally substituted aromatic group; Q represents a divalent aliphatic hydrocarbon group; R1 represents hydrogen, cyano, an optionally substituted hydrocarbon group, a group of the formula: STR2 wherein R3 and R4 independently represent hydrogen, acyl or an optionally substituted hydrocarbon group, or R3 and R4 jointly form a ring, or acyl; R2 represents acyl; ......... represents a single bond or a double bond; m represents 1 or 2 or a salt, a process of producing thereof and an anti-neurodegenerative composition.
Quinone derivatives, their production and use
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, (2008/06/13)
Quinone derivatives of the general formula: STR1 (wherein R1 and R2 are the same or different, and independently are a hydrogen atom or a methyl or methoxy group, or R1 and R2 combine with each other to represent --CH=CH--CH=CH--R3 is a hydrogen atom or a methyl group; R4 is an aliphatic, aromatic or heterocyclic group which may be substituted; R5 is a methyl or methoxy group, a hydroxymethyl group which may be substituted or a carboxyl group which may be esterified or amidated; Z is a group represented by --C=C--, --CH=CH--, STR2 n is an integer of 0 to 10; m is an integer of 0 to 3; k is an integer of 0 to 5, provided, however, that in the case of m being 2 or 3, Z and k can vary arbitrarily within the bracketed repeating units) are novel compounds, possess metabolism ameliorating action for polyunsaturated fatty acids, particularly production inhibitory activity of lipid peroxides (antioxidant activity), thromboxane A2 receptor antagonism, or production inhibitory activity of 5-lipoxygenase metabolites in mammals, and of use as drugs, such as antiasthmatic, antiallergic agent and cerebral-circulatory metabolism ameliorating agent.
