50978-45-5

Usage

Uses

Used in Chemical Synthesis:
N-ForMylsaccharin is used as a reagent for chemoselective N-formylation of primary and secondary amines, which is crucial in the synthesis of various organic compounds and pharmaceuticals. This selective formylation process allows for the targeted modification of specific amine groups in complex molecules, facilitating the development of new chemical entities and improving the efficiency of chemical reactions in research and industrial applications.

Upstream product

• 108-24-7 acetic anhydride 
• 81-07-2 saccharin 
• 2258-42-6 formyl acetic anhydride 

Downstream Products

• 2591-86-8 N-Formylpiperidine 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 141047-46-3 N-formyl-4-hydroxypiperidine 
• 23602-10-0 1,1-dimethylpropyl-formamide 
• 5279-58-3 N-[4-(propan-2-yl)phenyl]formamide 
• 19145-06-3 (S)-N-formyl-1-phenylethylamine 
• 87281-04-7 (R)-N-formyl-2-amino-2-phenylethanol 
• 766-93-8 N-cyclohexylformamide 
• 35517-65-8 N-Benzyl-N-tert.butylformamid (anti) 
• 23069-99-0 N-(2-phenylethyl)formamide 
• 2700-30-3 N,N-diisorpopylformamide 
• 103-70-8 Formanilid 
• 2843-27-8 N-(2-hydroxyphenyl)formamide 
• 41270-80-8 N-formylanthranilic acid methyl ester 

Relevant academic research and scientific papers

CARBON MONOXIDE PRODRUGS FOR THE TREATMENT OF MEDICAL DISORDERS

The present invention provides new compounds and compositions thereof that release carbon monoxide for the treatment of medical disorders that are responsive to carbon monoxide, for example, inflammatory, pain, and dermatological disorders.

A recyclable CO surrogate in regioselective alkoxycarbonylation of alkenes: Indirect use of carbon dioxide

Herein, we report a Pd-catalysed alkoxycarbonylation of alkenes based on the use of a recyclable CO2 reduction product, the crystalline and air-stable N-formylsaccharin, as a CO surrogate. The carbonylation proceeds under ambient conditions in an exceptionally complementary regioselective fashion yielding the desired branched products from styrene derivatives and valuable linear esters from alkyl-substituted alkenes.

N-Formylsaccharin: A new formylating agent

N-Formylsaccharin, a very cheap reagent, has been revealed to be an efficient and chemoselective formylating agent of amines. Georg Thieme Verlag Stuttgart New York.