10320-49-7

Basic information

• Product Name: 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
• Synonyms: 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one;3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one;(2-alpha-Naphthoylethyl)dimethylamine;2-(Dimethylamino)ethyl 1-naphthyl ketone;3-(dimethylamino)-1-(phthalen-5-yl)propan-1-one;1-Propanone,3-(dimethylamino)-1-(1-naphthalenyl)-
• CAS NO: 10320-49-7
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.30158
• Product Categories: bedaquiline intermediates
• Mol File: 10320-49-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 368.7°C at 760 mmHg
• Flash Point: 139.4°C
• Appearance: /
• Density: 1.072
• Vapor Pressure: 1.25E-05mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 8.78±0.28(Predicted)
• CAS DataBase Reference: 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one(10320-49-7)
• EPA Substance Registry System: 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one(10320-49-7)

Safety Data

• Hazardous Substances Data: 10320-49-7(Hazardous Substances Data)

Usage

Uses

3-(Dimethylamino)-1-(1-Naphthalenyl)-1-Propanone is a compound related to TMC207 which is used in the treatment of drug-resistant tuberculosis, and was studied for its anti-tubercular activity.

InChI:InChI=1/C15H17NO/c1-16(2)11-10-15(17)14-9-5-7-12-6-3-4-8-13(12)14/h3-9H,10-11H2,1-2H3

Upstream product

• 941-98-0 1'-naphthacetophenone 
• 506-59-2 N,N-dimethylammonium chloride 
• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 
• 5409-58-5 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one hydrochloride 
• 654655-80-8 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol 

Downstream Products

• 1228594-68-0 (1S,2R)-4-dimethylamino-2-(1-naphthyl)-1-phenyl-(6-bromo-2-chloro-quinolin-3-yl)-butan-2-ol 
• 1228594-69-1 (1R,2S)-4-dimethylamino-2-(1-naphthyl)-1-phenyl-(6-bromo-2-chloro-quinolin-3-yl)-butan-2-ol 
• 654653-93-7 (6-bromo-2-memoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol 
• 654653-93-7 rac-(1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-dimethylamino-2-(1-naphthyl)-1-phenylbutan-2-ol 
• 843663-66-1 bedaquiline 
• 654655-80-8 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol 
• 115066-04-1 2-(alpha-naphthoyl)ethyltrimethylammonium iodide 

Relevant articles and documents

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SMALL MOLECULE CMKLR1 ANTAGONISTS IN INFLAMMATORY DISEASE

α-NETA analogs are provided for the treatment of inflammatory disease.

New 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ols with antituberculosis activity

New 4-dimethylamino-2-(naphthalen-1-yl)-1-phenyl-1-(quinolin-3-yl)butan-2-ols with antituberculosis activity were synthesized. (1R*,2S*)-1-(6-Bromo-2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ol hydrocitrate exhibiting high

PYRIDINE DERIVATIVES AND APPLICATION OF ANTI-MACOBACTERIUM THEREOF

The present invention provides a series of pyridine derivatives and their preparation method and application thereof. The series of pyridine derivatives can be applied to treating mycobacterium-related diseases, especially to treatments of fatal mycobacterium-related diseases. The fatal diseases may be related to mycobacterium tuberculosis, mycobacterium bovis, mycobacterium avium, and mycobacterium marinum.