3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one

Base Information

• Chemical Name: 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
• CAS No.: 10320-49-7
• Molecular Formula: C15H17 N O
• Molecular Weight: 227.306
• Hs Code.: 2922399090
• Mol file: 10320-49-7.mol

Synonyms:1'-Propionaphthone,3-(dimethylamino)- (7CI,8CI); (2-a-Naphthoylethyl)dimethylamine

Chemical Property of 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one

Chemical Property:

• Vapor Pressure: 1.25E-05mmHg at 25°C
• Boiling Point: 368.7°C at 760 mmHg
• PKA: 8.78±0.28(Predicted)
• Flash Point: 139.4°C
• PSA: 20.31000
• Density: 1.072
• LogP: 2.97420
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

3-(Dimethylamino)-1-(naphthalen-1-yl)propan-1-one 95-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(Dimethylamino)-1-(1-Naphthalenyl)-1-Propanone is a compound related to TMC207 which is used in the treatment of drug-resistant tuberculosis, and was studied for its anti-tubercular activity.

Technology Process of 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one

There total 8 articles about 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one hydrochloride (5409-58-5) → 3-(dimethylamino)-1-(1-naphthalenyl)-1-propanone (10320-49-7)

Guidance literature:

With sodium hydroxide; In water; toluene; at 20 ℃; for 0.416667 - 0.666667h;

Reference yield: 89.0%

1'-naphthacetophenone (941-98-0) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + N,N-dimethylammonium chloride (506-59-2) → 3-(dimethylamino)-1-(1-naphthalenyl)-1-propanone (10320-49-7)

Guidance literature:

1'-naphthacetophenone; formaldehyd; N,N-dimethylammonium chloride; In ethanol; for 2h; Reflux;

With sodium hydrogencarbonate; In water;

DOI:10.1016/j.bioorg.2020.104054

Reference yield: 55.0%

1'-naphthacetophenone (941-98-0) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + dimethyl amine (124-40-3) → 3-(dimethylamino)-1-(1-naphthalenyl)-1-propanone (10320-49-7)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Heating;

upstream raw materials:

1'-naphthacetophenone

N,N-dimethylammonium chloride

formaldehyd

dimethyl amine

Downstream raw materials:

bedaquiline

1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol

(R,S)-bedaquiline

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