103203-84-5

Usage

Uses

Used in Chemical Synthesis:
Chroman-6-carboxylic acid is used as a key intermediate for the preparation and amidation in the synthesis of reactive fluorescent stains. Its carboxylic acid group enables it to undergo various chemical reactions, such as amide bond formation, which is crucial for the development of novel fluorescent stains with specific properties and applications.
Used in Fluorescent Stain Industry:
Chroman-6-carboxylic acid is used as a precursor in the synthesis of reactive fluorescent stains for various applications. These stains are essential in fields such as biochemistry, molecular biology, and cell biology, where they are used for labeling, imaging, and tracking of biomolecules, cells, and tissues. The unique properties of chroman-6-carboxylic acid contribute to the development of fluorescent stains with improved brightness, stability, and specificity.

InChI:InChI=1/C10H10O3/c11-10(12)8-3-4-9-7(6-8)2-1-5-13-9/h3-4,6H,1-2,5H2,(H,11,12)

Upstream product

• 58621-52-6 1-<6-(3,4-dihydro-2H-1-benzopyranyl)>ethanone 
• 493-08-3 chromane 

Downstream Products

• 155863-05-1 1-<2-(2,5-dioxo-1H-pyrrol-1-yl)ethyl>-4-<2-<6-(3,4-dihydro-2H-1-benzopyranyl)>-5-oxazolyl>pyridinium trifluoromethanesulfonate 
• 155863-03-9 1-<3-<1-(2,5-dioxopyrrolidinyl)oxycarbonyl>phenylmethyl>-4-<2-<6-(3,4-dihydro-2H-1-benzopyranyl)>-5-oxazolyl>pyridinium bromide 
• 155863-01-7 1-<2-(thiocarbonylamino)phenylmethyl>-4-<2-<6-(3,4-dihydro-2H-1-benzopyranyl)>-5-oxazolyl>pyridinium bromide 
• 155863-02-8 1-<2-(thiocarbonylamino)ethyl>-4-<2-<6-(3,4-dihydro-2H-1-benzopyranyl)>-5-oxazolyl>pyridinium bromide 
• 55746-03-7 Chroman-6-carbonyl chloride 

Relevant academic research and scientific papers

Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists

A novel set of azabicyclic aryl amides have been identified as potent and selective agonists of the α7 nAChR. A two-pronged approach was taken to improve the potential hERG liability of previously disclosed α7 nAChR agonist, PNU-282,987, while maintaining the compound's other desirable pharmacological properties. The first approach involved further exploration of the aryl carboxylic acid fragment of PNU-282,987, while the second approach focused on modification of the azabicyclic amine portion of PNU-282,987. The best compounds from each series are characterized by rapid brain penetration, good oral bioavailability in rat, and demonstrate in vivo efficacy in a rat P50 auditory sensory gating assay. At least one analog from each series (1h, 1o, 2a, 9a, and 18a) shows an improved hERG safety profile over PNU-282,987.

Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease

The invention provides compounds of Formula I: wherein Azabicyclo is any of: These compounds may be in the form of pharmaceutical salts or compositions, and racemic mixtures or pure enantiomers thereof. The compounds of Formula I are useful in pharmaceuticals in which α7 is known to be involved.

Syntheses of Reactive Fluorescent Stains Derived from 5(2)-Aryl-2(5)-(4-pyridyl)oxazoles and Bifunctionally Reactive Linkers

Several bifunctionally reactive linkers containing halide or sulfonate ester groups were prepared.The linkers were used to quaternize 5-(4-methoxyphenyl)-2-(4-pyridyl)oxazole and 2-(6-chromanyl)-5-(4-pyridyl)oxazole to produce fluorescent stains that contained a reactive group such as an isothiocyanate, an N-hydroxysuccinimidyl ester, a maleimide, or an oxirane.The stains were derivatized with either 1-propyl-amine, 1-propanethiol, or piperidine, as appropriate, to help in characteriazation.The stains may serve as more photostable alternatives to fluoresceins or coumarins.