103204-83-7

Upstream product

• 2142-73-6 1-(2,5-dimethylphenyl)-1-ethanone 
• 106-42-3 para-xylene 
• 79-37-8 oxalyl dichloride 
• 553-94-6 4-bromo-m-xylene 
• 80120-31-6 ethyl 2-(2,5-dimethylphenyl)-2-oxoacetate 

Downstream Products

• 124-38-9 carbon dioxide 
• 5779-94-2 2,5-dimethylbenzaldehyde 
• 610-72-0 2,5-dimethylbenzoic acid 
• 1173692-57-3 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazole]-1-piperidinyl]-2-(2,5-dimethylphenyl)-1,2-ethanedione 

Relevant academic research and scientific papers

Copper-catalyzed direct α-ketoesterification of propiophenones with acetophenones via C(sp3)-H oxidative cross-coupling

A novel copper-catalyzed direct α-ketoesterification of propiophenones with acetophenones via C(sp3)-H oxidative cross-coupling was developed. The reaction utilized O2 as a clean oxidant with high atom economy and the starting materials are facile and commercially available.

Intermolecular Radical Addition to Ketoacids Enabled by Boron Activation

The intermolecular radical addition to the carbonyl group is difficult due to the facile fragmentation of the resulting alkoxyl radical. To date, the intermolecular radical addition to ketones, a valuable approach to construct quaternary carbon centers, remains a formidable synthetic challenge. Here, we report the first visible-light-induced intermolecular alkyl boronic acid addition to α-ketoacids enabled by the Lewis acid activation. The in situ boron complex formation is confirmed by various spectroscopic measurements and mechanistic probing experiments, which facilitates various alkyl boronic acid addition to the carbonyl group and prevents the cleavage of the newly formed C-C bond. Diversely substituted lactates can be synthesized from readily available alkyl boronic acids and ketoacids at room temperature merely under visible light irradiation, without any additional reagent. This boron activation approach can be extended to alkyl dihydropyridines as radical precursors with external boron reagents for primary, secondary, and tertiary alkyl radical additions. The pharmaceutically useful anticholinergic precursors are easily scaled up in multigrams under metal-free conditions in flow reactors.

FUNGICIDAL HETERCYCLIC COMPOUNDS

Disclosed are compounds of Formula (1), including all geometric and stereoisomers, N-oxides, and salts thereof, formula (1) wherein E, R2, G, Z1, J and n are as defined in the disclosure. Also disclosed are compositions containing th