103216-19-9Relevant academic research and scientific papers
Synthesis of Steroidal Pyrazoles
Ahmad, M. S.,Alam, Zafar,Ali, S.M.
, p. 959 (2007/10/02)
Stigmast-4-en-6-one (I) reacts with phenylhydrazine to afford the pyrazole (VI) whereas with 6-oxostigmast-4-en-3β-yl acetate (II) and stigmast-4-ene-3,6-dione (III) the same pyrazole (VII) is obtained.Cholesta-2,4-dien-6-one (IV) gives the pyrazole (VIII).The epoxyketone (V) provides the pyrazole (IX).The structures of the products are supported by their elemental analyses and spectral data.
Reaction of Phenylhydrazine with α,β-Unsaturated Steroidal Ketones: Synthesis of Steroidal Pyrazoles
Ahmad, M. S.,Ansari, Shamim A.,Ali, S. Masarrat
, p. 910 - 913 (2007/10/02)
Reaction of 4-cholesten-6-one (I) with phenylhydrazine in the presence of acetic acid gives 2'-phenyl-4-cholestenopyrazole (V) whereas 6-oxo-4-cholesten-3β-yl acetate (II) and 4-cholestene-3,6-dione (III) afford the same pyrazole, 3-oxo-2'-phenyl-4-cholestenopyrazole (VI). 6β-Bromo-4-cholesten-3-one (IV) gives besides the pyrazole VI, 2'-phenyl-4-cholestenopyrazol-3-one phenylhydrazone (VII) which is also obtained by treating VI with phenylhydrazine.The structures are supported mainly by their spectral behaviour and chemical properties.Probable pathways for their formation have also been suggested.
