104596-45-4

Upstream product

• 1258-35-1 (3S,5R,6R,8S,9S,10R,13R,14S,17R)-5-bromo-6-hydroxy-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate 

Downstream Products

• 103216-19-9 3-oxo-2'-phenyl-4-cholesteno<4,6-cd>pyrazole 
• 66603-15-4 2'-phenyl-4-cholesteno<4,6-cd>pyrazole 
• 103216-20-2 2'-phenyl-4-cholesteno<4,6-cd>pyrazol-3-one phenylhydrazone 
• 1408324-44-6 3β-acetoxy-4'-phenyl-3',4,-dihydropyrimidino[6',5':6,7]cholest-4-ene-2'(1'H)-thione 
• 143488-96-4 methyl 3-methoxy-5-oxo-5,6-secocholestan-6-oate 
• 14772-40-8 methyl 5-oxo-5,6-secocholest-3-en-6-oate 
• 104527-35-7 5,6-seco-5-oxo-3,4-cholesten-6-oic acid 
• 10473-42-4 3β-acetoxy-5-oxo-5,6-seco-cholestan-6-oic acid 
• 570-46-7 5α-cholestan-6-one 
• 570-91-2 3β-hydroxycholest-4-en-6-one 
• 103216-21-3 2'-phenyl-3-cholesteno<4,6-cd>pyrazole 

Relevant academic research and scientific papers

Reaction of Organic Halides with Chlorotris(triphenylphosphine)cobalt(I)

Reaction of various types of organic halides with a monovalent cobalt complex, chlorotris(triphenylphosphine)cobalt(I) is described.Reaction of benzylic monohalides, dihalides and trihalides with CoCl(Ph3P)3 gave a coupling product with formation of a carbon-carbon single bond, double bond and triple bond, respectively, under mild and non-basic conditions.Dehalogenation of non-benzylic vicinal dihalides with the reagent took place cleanly to give an olefin in high yield.Reductive coupling of allylic halides using the reagent afforded regioselectively a 1,5-diene with retention of the stereochemistry of the carbon-carbon double bond of the allylic halides used.By using this reaction, (E,E,E,E)-squalene was stereospecifically synthesized from (E,E)-farnesyl bromide.Reaction of halohydrins with CoCl(Ph3P)3 gave exclusively a ketone in the presence of an amine or olefin through an alkylcobalt intermediate.A 1,2-hydrogen shift is involved in this reaction.Keywords - chlorotris(triphenylphosphine)cobalt(I); coupling reaction; benzylic halides; allylic halides; synthesis of 1,5-diene; squalene; halohydrin; ketone synthesis.