1032174-22-3

Basic information

• Product Name: 3-(4-methoxy-3-nitrophenyl)-1,5-bis-(4-methoxyphenyl)-4-methyl-1H-pyrazole
• Synonyms: 3-(4-methoxy-3-nitrophenyl)-1,5-bis-(4-methoxyphenyl)-4-methyl-1H-pyrazole
• CAS NO: 1032174-22-3
• Molecular Weight: 445.475
• Mol File: 1032174-22-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-methoxy-3-nitrophenyl)-1,5-bis-(4-methoxyphenyl)-4-methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxy-3-nitrophenyl)-1,5-bis-(4-methoxyphenyl)-4-methyl-1H-pyrazole(1032174-22-3)
• EPA Substance Registry System: 3-(4-methoxy-3-nitrophenyl)-1,5-bis-(4-methoxyphenyl)-4-methyl-1H-pyrazole(1032174-22-3)

Safety Data

• Hazardous Substances Data: 1032174-22-3(Hazardous Substances Data)

Upstream product

• 121-97-1 4-Methoxypropiophenone 
• 100-09-4 4-methoxybenzoic acid 
• 100-66-3 methoxybenzene 
• 103204-39-3 1-(4-methoxy-3-nitrophenyl)-propan-1-one 
• 7464-46-2 p-nitrophenyl p-methoxybenzoate 
• 1032174-14-3 1-(4-methoxy-3-nitrophenyl)-3-(4-methoxyphenyl)-2-methyl-propane-1,3-dione 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 

Relevant articles and documents

Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands

Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERα and ERβ was determined. Among compounds tested, the 2-nitrophenol derivative 5c was found to bind satisfactorily to both estrogen receptor subtypes (RBAα=5.17 and RBAβ=3.27). In general, the introduction of a nitro group into the A ring of these compounds was found to benefit their ERβ binding abilities.