7464-46-2

Basic information

• Product Name: 4-nitrophenyl 4-methoxybenzoate
• Synonyms: 4-nitrophenyl 4-methoxybenzoate;4-(4'-Methoxybenzoyloxy)nitrobenzene
• CAS NO: 7464-46-2
• Molecular Formula: C₁₄H₁₁NO₅
• Molecular Weight: 273.243
• Mol File: 7464-46-2.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 448.2 °C at 760 mmHg
• Flash Point: 202.5 °C
• Appearance: /
• Density: 1.309 g/cm³
• Vapor Pressure: 3.16E-08mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-nitrophenyl 4-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitrophenyl 4-methoxybenzoate(7464-46-2)
• EPA Substance Registry System: 4-nitrophenyl 4-methoxybenzoate(7464-46-2)

Safety Data

• Hazardous Substances Data: 7464-46-2(Hazardous Substances Data)

Usage

General Description

4-nitrophenyl 4-methoxybenzoate is a chemical compound that consists of a nitrophenyl group and a methoxybenzoate group. It is a yellow crystalline solid that is insoluble in water, but soluble in organic solvents. 4-nitrophenyl 4-methoxybenzoate is commonly used as a reagent in organic synthesis and as a building block in the production of pharmaceuticals and agrochemicals. It undergoes various chemical reactions such as esterification, hydrolysis, and reduction, making it versatile for use in different chemical processes. Additionally, 4-nitrophenyl 4-methoxybenzoate is a potential mutagen and should be handled with caution in laboratory settings.

InChI:InChI=1/C14H11NO5/c1-19-12-6-2-10(3-7-12)14(16)20-13-8-4-11(5-9-13)15(17)18/h2-9H,1H3

Upstream product

• 100-02-7 4-nitro-phenol 
• 100-09-4 4-methoxybenzoic acid 
• 830-03-5 4-nitrophenol acetate 
• 6343-26-6 1-(4-Methoxybenzoyl)pyrrolidine-2,5-dione 
• 24067-17-2 4-nitrophenylboronic acid 
• 696-62-8 para-iodoanisole 
• 104-88-1 4-chlorobenzaldehyde 
• 104-93-8 p-methylanizole 
• 555-16-8 4-nitrobenzaldehdye 
• 105-13-5 4-Methoxybenzyl alcohol 
• 123-11-5 4-methoxy-benzaldehyde 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 100-07-2 4-methoxy-benzoyl chloride 
• 824-78-2 4-nitrophenol sodium salt 

Downstream Products

• 94-30-4 ethyl 4-methoxybenzoate 
• 14609-74-6 p-nitrophenolate 
• 24561-40-8 C₁₂H₁₃NO₄ 
• 100-02-7 4-nitro-phenol 
• 14271-83-1 4-methoxybenzoyl cyanide 
• 263717-50-6 3,5-bis(4-methoxyphenyl)-4-methyl-1-phenyl-1H-pyrazole 
• 234093-24-4 4-ethyl-3,5-bis(4-methoxyphenyl)-1-phenyl-1H-pyrazole 
• 322399-92-8 4-isobutyl-3,5-bis(4-methoxyphenyl)-1-phenyl-1H-pyrazole 
• 263717-51-7 3,5-bis(4-methoxyphenyl)-1-phenyl-4-propyl-1H-pyrazole 
• 234093-26-6 4-ethyl-1,3,5-tris(4-methoxyphenyl)-1H-pyrazole 
• 322399-93-9 4-butyl-3,5-bis(4-methoxyphenyl)-1-phenyl-1H-pyrazole 
• 322399-94-0 4-isobutyl-1,3,5-tris(4-methoxyphenyl)-1H-pyrazole 
• 263717-52-8 4-n-propyl-1-(4-methoxyphenyl)-3,5-bis(4-methoxyphenyl)pyrazole 
• 263717-53-9 1,3,5-tris(4-hydroxyphenyl)-4-propylpyrazole 

Relevant articles and documents

Transition-Metal-Free DMAP-Mediated Aromatic Esterification of Amides with Organoboronic Acids

A new, transition-metal-free, effective method for aromatic esterification of amides with organoboronic acids has been developed. A wide range of benzoate derivatives were obtained with yields ranging from moderate to good. The catalytic reaction shows a broad substrate scope and excellent functional group tolerance. Conceptually, DMAP mediates the reaction and is crucial for this transformation.

The heteropolyacid catalyzed phenol method for synthesizing Arylester

The invention discloses a synthesis method of phenol by aromatic esterification by using heteropoly acid as a catalyst. The method comprises the following steps: adding fatty acid substituted phenol ester I, substituted benzoic acid II, reaction solvent and heteropoly acid into a reaction vessel provided with a thermometer, a water separator and a stirrer, reacting at 110-170 DEG C for 0.5-10 hours, wherein the reaction progress is monitored by TLC (thin layer chromatography) in the reaction process; and after the reaction is finished, centrifuging the reaction solution, taking the supernate, washing to remove the solvent, and carrying out recrystallization or column chromatography on the crude product to obtain the aromatic ester compound III. By using the heteropoly acid as the catalyst, compared with the traditional esterification reaction, the method disclosed by the invention has the advantages of simple after-treatment, and low pollution and environment friendliness due to use of a small amount of acid. The heteropoly acid is a solid acid, and can be recycled by filtration after the reaction is finished. The aromatic esterification reaction of exchanging ester with phenol is adopted to avoid the side reaction caused by high oxidation tendency of the substituted phenol in the reaction, so that the method is simpler to operate and has higher yield.

Ruthenium/NHC-catalyzed tandem benzylic oxidation/oxidative esterification of benzylic alcohols with phenols

An efficient methodology to access benzoate derivatives via tandem benzylic oxidation/oxidative esterification of benzylic alcohols with phenols catalyzed by ruthenium/NHC was developed. This operationally simple one-pot process uses O2 as the clean oxidant, producing esters in good to excellent yields.