10322-03-9

Usage

Uses

Used in Pharmaceutical Industry:
Cholesteryl butyl ether is used as an emulsifier, emollient, and stabilizer for enhancing the solubility of other substances and improving the texture and stability of formulations in pharmaceutical products such as lotions, creams, and ointments.
Used in Cosmetic Industry:
In the cosmetic industry, cholesteryl butyl ether serves a similar role as in pharmaceuticals, acting as an emulsifier, emollient, and stabilizer to improve the consistency and performance of cosmetic products.
Used in Drug Delivery Systems:
Cholesteryl butyl ether is utilized in drug delivery systems due to its amphiphilic nature, which facilitates its interaction with both water and lipid phases, thus enhancing the delivery and bioavailability of drugs.
Used in Liposomal Formulations:
As a component in liposomal formulations, cholesteryl butyl ether contributes to the stability and effectiveness of these delivery systems, taking advantage of its ability to interact with both aqueous and lipid environments.

InChI:InChI=1/C31H54O/c1-7-8-20-32-25-16-18-30(5)24(21-25)12-13-26-28-15-14-27(23(4)11-9-10-22(2)3)31(28,6)19-17-29(26)30/h12,22-23,25-29H,7-11,13-21H2,1-6H3

Upstream product

• 57-88-5 cholesterol 
• 71-36-3 butan-1-ol 
• 1182-65-6 cholesteryl p-toluenesulfonate 
• 910-31-6 cholesteryl chloride 
• 6901-51-5 cholesteryl-dichloro phosphate 
• 57-88-5 cholesterol 
• 109-65-9 1-bromo-butane 

Relevant academic research and scientific papers

Synthesis and characterisation of new types of side chain cholesteryl polymers

A series of cholesterol derivatives have been synthesised via the alkylation reaction of the 3-hydroxyl group with the aliphatic bromide compounds with different chain lengths, namely 3β-alkyloxy-cholesterol. The double bond between the C5 and C6 positions in these cholesterol derivatives was oxidised into epoxy, followed by an epoxy-ring-opening reaction with the treatment with acrylic acid, resulting in a series of 3β-alkyloxy-5α- hydroxy-6β-acryloyloxycholesterol, CnOCh (n = 1, 2, 4, 6, 8, 10, 12), The acrylate group is connected to the C6 position, which is confirmed by the single crystal structure analysis. The corresponding polymers, PC nOCh, were prepared via free radical polymerisation. The structure of monomers and the resulting polymers were characterised with nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT-IR) and gel permeation chromatography (GPC). The thermal properties of PCnOCh were studied using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). To determine the secondary structure of polymers, circular dichroism (CD) spectra were performed. It was found that not all monomers produce high-molecular-weight polymers because of steric hindrance. However, all polymers have a helical structure, which can be enhanced by increasing the alkoxy chain length. In addition, increasing the alkoxy chain length decreases the glass transition temperature and increases the decomposition temperature of the polymers.

Montmorillonite Clay Catalysis. Part 13.1 Etherification of Cholesterol Catalysed by Montmorillonite K-10

The preparation of cholesteryl ethers from alcohols and phenols with cholesterol is carried out at 50-70 °C by using montmorillonite K-10 as an acid catalyst in chloroform or cyclohexane.

SOLVOLYSIS OF 3β-CHLORO-5-CHOLESTENE IN THE PRESENCE OF ZINC SALTS

When heated in alcohols in the presence of zinc chloride 3β-chloro-5-cholestene undergoes solvolysis, and cholesterol ethers are formed with high yields.The same direction of reaction is preserved if the zinc chloride is formed directly in the reaction mixture.

The Synthesis of Cholesteryl Alkyl Ethers

Seventeen cholesteryl alkyl ethers were synthesized through alcoholysis of cholesterol p-toluenesulfonate.This method was found superior to the etherification of sodium or potassium cholesterylate with alkyl halides or methanesulfonates, especially for the preparation of long-chain unsaturated alkyl ethers of cholesterol of high specific activity.