103247-89-8

Basic information

• Product Name: 4-(4-BROMOPHENYL)-2-AZETIDINONE
• Synonyms: 4-(4-BROMOPHENYL)-2-AZETIDINONE;4-(4-bromophenyl)azetidin-2-one
• CAS NO: 103247-89-8
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.072
• Mol File: 103247-89-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 104-108 °C(Solv: isopropyl ether (108-20-3))
• Boiling Point: 399.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.571±0.06 g/cm3(Predicted)
• PKA: 14.89±0.40(Predicted)
• CAS DataBase Reference: 4-(4-BROMOPHENYL)-2-AZETIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-BROMOPHENYL)-2-AZETIDINONE(103247-89-8)
• EPA Substance Registry System: 4-(4-BROMOPHENYL)-2-AZETIDINONE(103247-89-8)

Safety Data

• Hazardous Substances Data: 103247-89-8(Hazardous Substances Data)

Upstream product

• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 103247-88-7 4-(4-Bromphenyl)-2-azetidinon-N-sulfonylchlorid 

Downstream Products

• 930769-50-9 (S)-4-(4-bromophenyl)-2-azetidinone 
• 948027-09-6 C₉H₈BrNO 
• 130973-06-7 p-bromocinnamamide 
• 1407189-13-2 N-(benzyl)-4-(4-bromophenyl)-azetidin-2-one 
• 1372804-72-2 3-(4-bromophenyl)-3-phenylpropionamide 
• 7474-19-3 3,3-diphenylpropionamide 
• 930769-56-5 (S)-3-Amino-3-(4-bromo-phenyl)-propionic acid; hydrochloride 
• 479074-63-0 (R)-3-amino-3-(4-bromo-phenyl)-propionic acid 

Relevant articles and documents

The acid-mediated ring opening reactions of α-aryl-lactams

4-Aryl-azetidin-2-ones (β-lactams) undergo ring opening with triflic acid to give cinnamamides which, in benzene, react further to give 3-aryl-3-phenyl-propionamides. Prolonged reaction times in benzene give 3,3-diphenyl-propionamide via an aryl/phenyl ex

The Reaction of 4-Phenyl-2-azetidinone with Aldehydes

The title compound 1 reacts with aliphatic aldehydes to yield N-(1-hydroxyalkyl) derivatives 5, which can be dehydrated to N-vinyl-β-lactams 6.The reaction of 1 with aromatic aldehydes gives amidols 9, from which the derivatives 10 are obtained by acylation.