1032573-76-4Relevant articles and documents
Discovery and optimization of a novel series of potent mutant B-Raf V600E selective kinase inhibitors
Vasbinder, Melissa M.,Aquila, Brian,Augustin, Martin,Chen, Huawei,Cheung, Tony,Cook, Donald,Drew, Lisa,Fauber, Benjamin P.,Glossop, Steve,Grondine, Michael,Hennessy, Edward,Johannes, Jeffrey,Lee, Stephen,Lyne, Paul,M?rtl, Mario,Omer, Charles,Palakurthi, Sangeetha,Pontz, Timothy,Read, Jon,Sha, Li,Shen, Minhui,Steinbacher, Stefan,Wang, Haixia,Wu, Allan,Ye, Minwei
, p. 1996 - 2015 (2013/05/09)
B-Raf represents an attractive target for anticancer therapy and the development of small molecule B-Raf inhibitors has delivered new therapies for metastatic melanoma patients. We have discovered a novel class of small molecules that inhibit mutant B-Raf
