95086-95-6

Upstream product

• 67-56-1 methanol 
• 18292-63-2 1-(p-bromobenzoyl)aziridine 
• 586-75-4 4-chlorobenzoyl chloride 
• 109-85-3 2-methoxyethylamine 

Downstream Products

• 1032573-61-7 N-(2-methoxyethyl)-4-{[6-(4-methylpyridin-3-yl)quinazolin-2-yl]amino}benzamide 
• 1425503-99-6 C₂₂H₂₀N₆O₂ 
• 1032573-72-0 4-{[6-(6-fluoropyridin-3-yl)quinazolin-2-yl]amino}-N-(2-methoxyethyl)benzamide 
• 1032573-74-2 N-(2-methoxyethyl)-4-{[6-(6-methoxypyridin-3-yl)quinazolin-2-yl]amino}benzamide 
• 1032573-76-4 N-(2-methoxyethyl)-4-[(6-pyridin-3-ylquinazolin-2-yl)amino]benzamide 
• 1425503-96-3 C₂₄H₂₂N₄O₂ 

Relevant academic research and scientific papers

KINASE MODULATORS AND METHODS OF USE THEREOF

The present invention relates to novel compounds that modulate the activity of one or more kinases, such as TYK2 or mutants thereof. The compounds, which may be kinase inhibitors or activators, are useful for treating autoimmune diseases, such as, such as psoriasis, lupus, multiple sclerosis, and inflammatory bowel disease.

Discovery and optimization of a novel series of potent mutant B-Raf V600E selective kinase inhibitors

B-Raf represents an attractive target for anticancer therapy and the development of small molecule B-Raf inhibitors has delivered new therapies for metastatic melanoma patients. We have discovered a novel class of small molecules that inhibit mutant B-Raf

CHEMICAL COMPOUNDS-576

The invention relates to chemical compounds of the formula (I): or pharmaceutically or pharmaceutically acceptable salts thereof, which possess B-Raf inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of trea

PYRIDINYLQUINAZ0LINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS

The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B-Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

Effect of para-Substituents on the Photochemical Rin-opening Reactivity of 1-(p-Substituted-benzoyl)aziridines in Methanol

Photolysis of 1-(p-substituted-benzoyl)aziridines (1a-e) in Ar-purged methanol led to N-(2-methoxyethyl)benzamides (3b-e) as the methanolysis products and/or N-ethylbenzamides (2a and b).Penta-1,3-diene quenched the formation of (2a and b) but not (3b-e).