1032579-01-3Relevant academic research and scientific papers
A new generation of specific Trypanosoma cruzi trans-sialidase inhibitors
Buchini, Sabrina,Buschiazzo, Alejandro,Withers, Stephen G.
, p. 2700 - 2703 (2008)
(Chemical Equation Presented) A substitution for inhibition: The incorporation of anaryl substituent at C9 of 3-fluorosialyl fluorides provides specificity and dramatically slows the reactivation of the glycosylphosphatidylinositol-anchored surface protein Trypanosoma cruzi trans-sialidase (TcTS) by transglycosylation (see picture). X-ray crystallographic analysis of the trapped intermediate has provided a structural rationale for this behavior.
